Research Lab Specialist Inter

4 weeks ago

Ann Arbor, Michigan, United States University of Michigan Health System Full time
How to Apply

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

Job Summary

The Nuttle laboratory in the Department of Human Genetics seeks a highly-motivated Intermediate Research Laboratory Specialist to serve as the Lab Manager.

The laboratory investigates neurodevelopmental disorders, human evolution, and genome technology development. The successful applicant will work closely with Dr. Nuttle to set up and manage his laboratory and will drive studies modeling neurodevelopmental disorders using induced pluripotent stem cells, CRISPR genome engineering, and brain organoids.

Mission Statement

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Who We Are

The Department of Human (DHG) Genetics at Michigan Medicine is recognized as the first dedicated human genetics department in the United States. The DHG is one of nine basic science departments in the Medical School with primary missions of teaching and research devoted to advancing the fields of genetics and genomics to further our understanding of biology and human disease. The Department is growing as faculty are presently being recruited. We enjoy social functions as a Department, including a yearly department picnic and a yearly department retreat.

Why Join Michigan Medicine?

Michigan Medicine is one of the largest health care complexes in the world and has been the site of many groundbreaking medical and technological advancements since the opening of the U-M Medical School in 1850. Michigan Medicine is comprised of over 30,000 employees and our vision is to attract, inspire, and develop outstanding people in medicine, sciences, and healthcare to become one of the world's most distinguished academic health systems. In some way, great or small, every person here helps to advance this world-class institution. Work at Michigan Medicine and become a victor for the greater good.

What Benefits can you Look Forward to?
  • Excellent medical, dental and vision coverage effective on your very first day
  • 2:1 Match on retirement savings
Responsibilities*
  • Design and perform cell culture experiments, including: Culture and maintain brain organoids, starting from induced pluripotent stem cell lines, perform experiments to characterize brain organoids (microscopy and morphological measurements; immunofluorescent staining, pooled-organoid RNA-seq, single-cell RNA-seq, and possibly additional assays such as proteomics); and assist with other experiments related to modeling neurodevelopmental disorders (iPSC culture, genome editing, preparation of CRISPR libraries).
  • Serve as the Lab Manager including: Oversee set-up of lab, purchase lab equipment, reagents, and supplies; organize and track inventory; organize biomaterials (cell lines, DNA/RNA samples. plasmids, etc.) and maintain equipment. Serve as the lab safety officer, coordinating documentation for safety inspections, keeping the lab IBC protocol updated, ensuring compliance with all regulations, and training new lab members in safe research practice
  • Analyze data using various data analysis programs. Prepare data for presenting, and present data.
  • Contribute to manuscripts, grants, and presentations, including written components, figures, and tables.
  • Read literature and attend seminars.
  • Supervise graduate students, undergraduate students, and research staff. Train lab members on safe research practices, key protocols, and experimental procedures.
Required Qualifications*
  • Master's degree in a relevant field of study (genetics, molecular biology, bioengineering, etc.).
  • At least 4 years of experimental laboratory experience.
  • Eagerness to perform cell culture experiments and grow brain organoid models.
  • Eagerness to learn new experimental approaches.
  • Strong motivation and perseverance.
  • Excellent communication and teamwork skills.
  • Strong organization skills.
Desired Qualifications*
  • Ph.D. degree in a relevant field of study (genetics, molecular biology, bioengineering, etc.) is preferred.
  • Five or more years of experimental laboratory experience.
  • Experience with cell culture.
  • Experience with brain organoid modeling.
  • Experience with microscopy, immunofluorescence, and RNA-seq library preparation and analysis.
  • Experience requesting purchases and maintaining inventory for a research lab.
  • Experience training/supervising graduate and undergraduate students.
  • Ability to commit to the position for at least 3 years.
Work Locations

It is expected all work associated with this position will occur in person.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the .

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.

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