Associate Director/Director, Bioinformatics
4 weeks ago
Acrivon is a clinical stage biopharmaceutical company developing precision oncology medicines that it matches to patients whose tumors are predicted to be sensitive to each specific medicine by utilizing Acrivon's proprietary proteomics-based patient responder identification platform, Acrivon Predictive Precision Proteomics, or AP3. The AP3 platform is engineered to measure compound-specific effects on the entire tumor cell protein signaling network and drug-induced resistance mechanisms in an unbiased manner. These distinctive capabilities enable AP3's direct application for drug design optimization for monotherapy activity, the identification of rational drug combinations, and the creation of drug-specific proprietary OncoSignature companion diagnostics that are used to identify the patients most likely to benefit from Acrivon's drug candidates.
Acrivon is currently advancing its lead candidate, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial across multiple tumor types. The company has received Fast Track designation from the Food and Drug Administration, or FDA, for the investigation of ACR-368 as monotherapy based on OncoSignature-predicted sensitivity in patients with platinum-resistant ovarian or endometrial cancer. Acrivon's ACR-368 OncoSignature test, which has not yet obtained regulatory approval, has been extensively evaluated in preclinical studies, including in two separate, blinded, prospectively-designed studies on pretreatment tumor biopsies collected from past third-party Phase 2 trials in patients with ovarian cancer treated with ACR-368. The company has reported initial positive clinical data from its ongoing registrational-intent Phase 2b trial of ACR-368 for patients with locally advanced or metastatic, recurrent platinum-resistant ovarian cancer or endometrial adenocarcinoma (data cut as of April 1, 2024), including a confirmed ORR (per RECIST 1.1) of 50% in the prospective cohort of OncoSignature-positive patients who were efficacy-evaluable. The FDA has granted Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of ovarian cancer patients who may benefit from ACR-368 treatment. In addition to ACR-368, Acrivon is also leveraging its proprietary AP3 precision medicine platform for developing its co-crystallography-driven, internally-discovered preclinical stage pipeline programs. These include ACR-2316, a potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity as demonstrated in preclinical studies against benchmark inhibitors, and a cell cycle program with an undisclosed target.
Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.
Position Overview:
The Associate Director/Director, Bioinformatics within the Data Science team will play a key role in applying bioinformatics and computational biology expertise to drive innovative solutions for drug discovery and development, leveraging our AP3 platform. We are seeking an accomplished professional with a demonstrated record of integrating multi-omics data and computational methodologies to generate actionable biological insights. These insights should encompass target identification and validation, elucidation of mechanisms of action, exploration of therapeutic indications, and biomarker discovery. This role is based in Watertown, MA.
Duties and Responsibilities:
Drive the implementation of advanced AI/ML approaches and knowledge graph databases to enhance data interpretation and decision-making processes.
Identify emerging trends and technologies in bioinformatics, MS-proteomics and AI/ML approaches and integrate these advancements to the data science's workflows and pipeline.
Contribute to integration of internal and external data, ensuring the bioinformatics infrastructure is robust, scalable, and secure to handle large-scale data analyses.
Foster collaboration with other functions and communicate effectively to share scientific analyses and concepts.
Qualifications include:
PhD. or M.S. in Bioinformatics, Computational biology, Engineering, Computer Sciences, or a related field.
Demonstrated track record of 8+ years in applying bioinformatics or computational biology methodologies within an industry environment.
Deep understanding of bioinformatics tools, databases, and software, particularly in the context of MS-proteomics and AI/ML applications.
Hands on experience in developing computational workflows and conducting data analyses for multi-omics datasets, with a particular emphasis on proteomics.
Strong programming skills in languages such as Python and R, alongside proficiency in other scripting languages.
Hands on experience with data integration techniques and devising relational database schema for managing, storing, and retrieving large-scale biological data.
Extensive experience in the oncology therapeutic area, including familiarity with cancer biology and treatment modalities.
Excellent communication and presentation skills with demonstrated record of peer-reviewed publication.
Team player with ability to nurture productive collaborative relationship with internal and external partner.
Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.
-
Assistant Director of Nursing
4 weeks ago
Watertown, Massachusetts, United States American Medical Associates Full timeAssistant Director of Nursing - Long-Term Care Facility Located in Watertown, MASalary up to $90K annually *Depending Upon Experience*Qualifications:Must have MA RN licenseMust have experience as an Assistant Director of NursingMust have long term care experienceProven Leadership & Management skillsStrong verbal & written communication skillsResponsibilities...
-
Director, Clinical Operations
1 month ago
Watertown, Massachusetts, United States Surf Search Full timePublicly Traded Biopharmaceutical company in Watertown, MA is expanding for their high profile clinical development trials.The Director, Clinical Operations is a leadership role responsible for overseeing and managing all aspects of clinical operations for a high priority immunology program. This individual possesses clinical operations expertise with a...
-
Water Resources Management Director
7 days ago
Watertown, Massachusetts, United States City of Watertown Full timeAbout the Role The City of Watertown seeks a highly motivated and experienced Water Resources Management Director to oversee all aspects of our water, wastewater, and hydroelectric operations. This is a unique opportunity to lead a dedicated team and make a tangible impact on the community's well-being. Key Responsibilities Provide strategic leadership and...
-
Associate Director
4 weeks ago
Watertown, Massachusetts, United States Novo Nordisk Full timeAbout the Department Our Boston Research & Development hub, anchored in the greater Boston area, brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown and Cambridge reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future,...
-
Revenue Cycle Coordinator
7 days ago
Watertown, Massachusetts, United States Benchmark Senior Living Full timeOverview The Revenue Cycle Coordinator plays a vital role in ensuring the financial health of our senior living communities. Reporting directly to the Director of Business Administration Operations, this position collaborates closely with the Senior Director of Financial Operations and other key stakeholders to manage revenue cycle processes and accounts...
-
Residential Care Specialist
7 days ago
Watertown, Massachusetts, United States HourlyWork Full timeHourlyWork - Residential Care Associates/CNAsThe HourlyWork organization is actively looking for both part-time and full-time residential care associates/CNAs to cover various shifts. We are dedicated to delivering outstanding support to our residents.Key ResponsibilitiesAssist residents with their daily living activities to enhance their autonomy.Support...
-
Residential Care Specialist
7 days ago
Watertown, Massachusetts, United States HourlyWork Full timeHourlyWork - Residential Care Associates/CNAsThe HourlyWork organization is actively seeking dedicated part-time and full-time residential care associates/CNAs for various shifts. Our mission is to deliver outstanding support to our residents.Key ResponsibilitiesAssist residents with daily living activities to enhance their autonomy.Support individuals with...
-
Senior Immunology Director
2 days ago
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full timeJob Title: Lead ImmunologistCompany: Stratacuity: Proven Scientific PlacementLocation: RemoteScience/Focus: Immunological DiseasesJob Overview: We are seeking a highly skilled Lead Immunologist to drive the development of innovative oral degrader programs and oversee translational immunology and inflammation projects. The ideal candidate will apply their...
-
Administrative Support Specialist
7 days ago
Watertown, Massachusetts, United States INSTITUTE FOR HEALTH Full timeJob OverviewPosition Title: Receptionist & Program AssistantDepartment: OperationsEmployment Type: Full-Time, 40 hours per week – Hybrid (remote and on-site)Location: WatertownReports To: Director of OperationsThe Institute for Health and Recovery (IHR) is a comprehensive service, research, policy, program development, and capacity-building organization....
-
Administrative Support Specialist
2 days ago
Watertown, Massachusetts, United States INSTITUTE FOR HEALTH Full timeJob OverviewPosition Title: Receptionist & Program AssistantDepartment: OperationsEmployment Type: Full-Time, 40 hours per week – Hybrid (remote and on-site)Location: WatertownSupervisor: Director of OperationsThe Institute for Health and Recovery (IHR) is a statewide organization dedicated to service, research, policy, program development, and capacity...
-
Administrative Support Specialist
2 days ago
Watertown, Massachusetts, United States INSTITUTE FOR HEALTH Full timeJob OverviewPosition Title: Receptionist & Program AssistantDepartment: OperationsEmployment Type: Full-Time, 40 hours per week – Hybrid (remote and on-site)Location: WatertownSupervisor: Director of OperationsThe Institute for Health and Recovery (IHR) is a comprehensive service, research, policy, program development, and capacity-building organization....
-
Revenue Cycle Management Specialist
7 days ago
Watertown, Massachusetts, United States Benchmark Senior Living Full timeOverview The Revenue Cycle Management Specialist plays a pivotal role in overseeing the financial processes associated with resident accounts in senior living environments. Reporting directly to the Director of Business Administration Operations, this position collaborates closely with various senior leadership roles to ensure efficient revenue cycle...
-
Immunology and Inflammation Program Director
2 days ago
Watertown, Massachusetts, United States Stratacuity: Proven Scientific Placement Full time**Job Title:** Lead Immunologist**Company:** Stratacuity: Proven Scientific Placement**Location:** Remote Opportunity**Science/Focus:** Immunological Diseases and Translational Research**Job Overview:** We are seeking a highly experienced Lead Immunologist to drive the development of innovative oral degrader programs and oversee translational immunology and...
-
Watertown, Massachusetts, United States HallKeen Assisted Living Communities LLC Full timePosition OverviewJob Title: Wellness Nurse RN/LPNLocation: Senior Living FacilitiesEmployment Type: Full TimeRole Summary:The Wellness Nurse plays a crucial role in supporting the Resident Care Director in the comprehensive execution, provision, and organization of Resident Care services within the community. This position also involves overseeing and...
-
Stocker
1 month ago
Watertown, Massachusetts, United States Hy - Vee Food Stores Full timeAt Hy-Vee our people are our strength.Accountable and Reports to: District Store Director, Store Manager, Assistant Managers of; Store Operations, Perishables, and Health Wellness Home, Service ManagersUnloads trucks, opens containers, stock the shelves, runs overstock on risers and rotates product.Monitors for mis-picked items, reviews product outs, wrong...
-
Physician - Psychiatrist
3 months ago
Watertown, Massachusetts, United States Department Of Veterans Affairs Full timeSummary The incumbent is a licensed psychiatrist with broad and experience in general medicine and in psychiatry. This individual conducts diagnostic and therapeutic interventions on an outpatient and/or inpatient basis to a wide age range of mental health patients within the Primary Care and Mental Health clinics. Additional duties include conducting...
-
Customer Success Manager
7 days ago
Watertown, Massachusetts, United States Thefairstream Full timeThefairstreamCustomer Success ManagerRemoteThefairstream is a technology-driven platform dedicated to connecting professionals with opportunities that enhance their work experience. We recognize that our team members are essential to the success of our operations and deserve acknowledgment, respect, and rewards for their efforts. Our platform provides...
-
Residential Care Support Specialist
7 days ago
Watertown, Massachusetts, United States HourlyWork Full timeHourlyWork - Residential Care Support SpecialistThe HourlyWork organization is actively looking for dedicated residential care support specialists to provide compassionate assistance to our residents.Key ResponsibilitiesAssist residents with daily living tasks to enhance their autonomy.Support individuals with personal hygiene, mobility aids, and medication...
-
Healthcare Financial Specialist
7 days ago
Watertown, Massachusetts, United States IASIS Healthcare Full timePosition Overview:The Financial Analyst at IASIS Healthcare plays a pivotal role in the financial planning and analysis department. This position involves the creation, examination, and upkeep of various financial statements that are crucial for supporting the strategic objectives and overall performance of the organization.Key Responsibilities:1. Manage...
-
Future Zusers
2 months ago
Watertown, Massachusetts, United States Zus Health Full timeWho we areZus is a shared health data platform designed to accelerate healthcare data interoperability by providing easy-to-use patient data via API, embedded components, and direct EHR integrations. Founded in 2021 by Jonathan Bush, co-founder and former CEO of athenahealth, Zus partners with HIEs and other data networks to aggregate patient clinical...