Senior Scientist, Engineering I
3 weeks ago
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us Follow @abbvie onTwitter,Facebook,Instagram,YouTubeandLinkedIn.
Job Description
Process Engineering, a part of AbbVie R&Ds Small Molecule CMC Development organization, is responsible for designing and developing scalable processes to make small molecule drug substances and drug products, including antibody drug conjugates (ADCs), throughout pre-clinical and clinical development stages. Process Engineering also partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support to enable robust process scale-up and manufacturing of biologics drug substances and drug products, including toxins and cosmetic active ingredients (CAIs). We contribute to the development of innovative engineering technologies and create valuable intellectual property through the composition of matter, chemical processes, and technologies resulting in cost-effective commercial manufacturing processes. We support the development of the supply chain for pipeline molecules and help prepare and defend CMC regulatory content.
Chemical/Bio Engineers support pipeline projects through all phases of development. Early in development, engineers focus on ensuring that the process can be run safely, identifying and addressing scale-up issues, enabling processes that can be scaled-up successfully. In the later stages of development, engineers optimize the drug substance and drug product processes and lead manufacturing campaigns. Engineers also work cross-functionally to transfer the optimized process to manufacturing sites, develop control strategy, and prepare reports to support regulatory filings.
Role Overview:
The successful candidate will play a key role in the Center of Excellence in Isolation and Separation Technologies (CoExIST), a part of Process Engineering function.The core deliverable of Process Engineering is to develop robust processes to manufacture small molecule Active Pharmaceutical Ingredients (API), ADCs, toxins, CAIs, and drug products utilizing strong engineering fundamentals. The idea candidate will have background in crystallization fundamentals and crystallization process development. Process Engineering also leads the development of isolation and purification strategies for both small and large molecule compounds. The ideal candidate will have a passion for hands-on laboratory process development and a proven track record in research and development. The candidate is also expected to lead the identification and development of novel approaches and technologies to enhance process development efficiency and commercialization. The candidate must exhibit a collaborative nature in identifying process challenges on a wide range of projects and participate in a cross-functional teams to deliver against specific project needs.
Key Responsibilities:
Develop robust scale up and manufacturing processes, supporting small and/or large molecule assets through all phases of development. Performlaboratory experiments and process modeling to support process understanding and optimization. Addresschallenging problems with separations, and/or isolations using expertise in thermodynamics, crystallization fundamentals, transport phenomena, and mathematical modeling. Author and/or review technical documents summarizing process development efforts. Exhibita collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectivelyby multi-disciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists. Author publications and present at scientific conferences.Qualifications
Qualifications: BS, MS, or PhD in Chemical/Bio Engineering or a related field and 10+ (BS), 8+ (MS), or 0+ (PhD) years of relevant industrial experience. Job level will be commensurate with academic and/or industrial work experience. Candidates are expected to have a strong background in chemical engineering and the proven ability to demonstrate their skills in this field. The candidate is expected to demonstrate the ability to learn, understand, and master new experimental techniques. The candidate is required to possess effective oral and written communication skills and be a strong team player. Preferred: Prior crystallization, isolation, or purification experience. Experience with Process Analytical Technologies (PAT). Experience with laboratory experimentation and process scale-up. Working knowledge of analytical techniques such as HPLC, FTIR, Raman, and microscopy. Familiarity with operation of chemical/biochemical process equipment and systems. Experience with mechanistic and/or process modeling or computational fluid dynamics. Key Leadership Competencies: Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance. Learns fast, grasps the essence, and can change course quickly where indicated. Raises the bar and is never satisfied with the status quo. Creates a learning environment, open to suggestions and experimentation for improvement. Embraces the ideas of others, nurtures innovation and enables innovation to reality.
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs. Note: No amount of payis a considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status. US & Puerto Rico only - to learn more, visit
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