Scientist II, Protein and Viral Vector Purification

3 weeks ago

Frederick, Maryland, United States Thermo Fisher Scientific Full time

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Able to lift 40 lbs. without assistance, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.), Will work with hazardous/toxic materials

Job Description

Thermo Fisher Scientific Inc. is seeking a highly motivated individual to join the Protein and Viral Vector Purification department as a Scientist II. This is a unique opportunity to be involved with groundbreaking research projects with the potential to make a significant impact in the scientific community. As part of a collaborative group, you will have the chance to work in a premier facility and collaborate with a diverse group of individuals who consistently demonstrate strong work behaviors.

US – Frederick, MD/BID

Responsibilities:

  • Conduct downstream activities including depth filtration, tangential flow filtration, and column-based purification of antibodies, non-antibody recombinant proteins, and viral vectors (primarily AAV and LV).
  • Develop methods to enhance the purification of proteins and viral vectors.
  • Perform analytical characterization of proteins and viral vectors, including concentration/titer, purity, aggregation, fragmentation, glycan profiles, charge variants, and biological activity.
  • Troubleshoot instrumentation hardware and software related issues for FPLC and HPLCs (e.g., AKTA Pure FPLC, AKTA Avant FPLC, and Vanquish UHPLC).
  • Design and conduct experiments, accurately analyze data, and interpret results.
  • Collaborate with cross-functional teams to ensure the successful implementation of research projects.
  • Share research findings with colleagues within the organization and present at scientific conferences.

Education:

  • Strong background in protein purification/characterization with a Bachelor's degree and 4+ years of relevant academic or industry experience, a Master's degree plus 0-3+ years of experience.

Requirements:

  • Extensive knowledge and experience in protein purification by column chromatography (affinity, IEX, NiNTA, reverse-phase, etc.).
  • Proficiency in protein purification and analytical characterization using standard laboratory techniques, including AKTA-FPLC, SDS-PAGE, Western Blot, SEC-HPLC, IEX-HPLC, RP-HPLC, HIC, HILIC, affinity chromatography, ELISA, ligand-binding assays, and functional cell-based assays.
  • Viral vector purification and characterization experience is a plus.
  • Knowledge of Mass Spectrometry-based proteomics is a plus.
  • Ability to efficiently implement technology transfer, particularly across sites.
  • Ability to think creatively and apply existing analytical technologies to new applications.
  • Familiarity with hardware and software for FPLC and HPLC instruments (e.g., AKTA Pure FPLC, AKTA Avant FPLC, and Vanquish UHPLC).
  • Track record of completing tasks within established timelines.
  • Excellent time management and multitasking capabilities.
  • Proficiency in handling multiple projects and prioritizing tasks efficiently.
  • Excellent verbal and written communication skills with the ability to present scientific results in a clear, concise, and accurate manner to both technical and non-technical audiences.
  • Ability to generate new insights, achieve results, and address problems.

Thermo Fisher Scientific Inc. is committed to fostering an inclusive and diverse workplace. We believe that our employees' unique perspectives and contributions drive our success and enable us to deliver solutions to our customers. Collaboration is at the heart of our culture, and we encourage our employees to share their ideas and expertise.

As an equal opportunity employer, Thermo Fisher Scientific Inc. provides reasonable accommodations/adjustments to qualified individuals with disabilities. We offer a competitive salary and benefits package, and our sophisticated facilities provide an outstanding work environment conducive to professional development and growth.

Driven scientists who are passionate about making a difference, we invite you to apply for the Scientist II position at Thermo Fisher Scientific Inc. Equivalent experience will also be considered.

Apply now and take the next step in your scientific research career

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