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Scientist
2 months ago
We are seeking a Scientist to support the National Institutes of Health's (NIH), world renowned National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, MD. Our NIAID professional, technical, and scientific support personnel are part of a preeminent team focused on positively impacting millions of lives around the world with groundbreaking research. Candidates will work at a prominent, diverse and vibrant NIAID worksite to directly support exciting ongoing research activities as a contractor team member. Accelerate your career and apply below to help us make a difference.
CAMRIS International is a dynamic clinical research and international development firm that achieves innovative solutions to health and development challenges through high-quality, cost-effective programs and research management services. We combine our proven systems with today's most effective, evidence-based best practices. Our core practice areas include: clinical research; vaccine research, microbiology and infectious disease research, development and production; biodefense; global health security; and HIV/AIDS programs.
Our employees enjoy a diverse, collegial environment where individual contributions matter at all levels. At CAMRIS, you will notably improve the lives of people at home and abroad.
Responsibilities
- Design of experiments utilizing rodent and non-human primate models to study vivo pharmacokinetic (PK) studies of monoclonal antibodies.
- Design and execution of experimental approaches to characterize monoclonal antibodies, including binding (ELISA and related techniques), measures of antibody affinity (biolayer interferometry or surface plasmon resonance approaches), and functional assays (including antibody-neutralization studies).
- Conduct animal studies to evaluate the immunogenicity of vaccines (including intramuscular, subcutaneous, intraperitoneal, and intravenous injection, sample collection and processing).
- Discover and characterize monoclonal antibodies.
- Monoclonal antibody production and purification from mammalian cells.
- Viral pseudotype or infectious virus production and characterization for use in antibody characterization studies.
- Perform maintenance for multiple cell culture lines used in laboratory experiments.
- Perform flow cytometry experiments.
- Manage colonies of mouse strains for studying antibody PK and VRC vaccine development programs.
- Represent the Virology Core at internal virtual product development meetings to provide subject matter expertise on antibody development and PK.
- Provide expert PK analysis in support of VRC regulatory submissions.
- Participate in the management and safe operation of the Virology Core laboratory including the maintenance of accurate records, inventories, shipping of biological materials, ordering, and training.
- Ph.D. in a relevant biomedical field with (3) years of experience of laboratory experience.
- Demonstrable expertise in laboratory studies involving antibody or biological pharmacokinetics.
- Expertise in the design of experiments to utilizing rodent and non-human primate models to study vivo pharmacokinetic (PK) studies of monoclonal antibodies.
- Demonstrable experience with small animal models.
- Expertise in the design and execution of experimental approaches to characterize monoclonal antibodies, including binding (ELISA and related techniques), measures of antibody affinity (biolayer interferometry or surface plasmon resonance approaches), and functional assays (including antibody-neutralization studies).
- Expertise in monoclonal antibody production and purification from mammalian cells.
- Detailed knowledge of pharmacokinetics, PK modeling, and the use of related data analysis tools (Phoenix WinNonlin, R, NONMEM, or other pharmacokinetic, modeling and data visualizations software).
- Willingness to work with infectious pathogens using BSL-2 containment.
- Exceptional organizational skills.
- Exceptional collaboration, coordination, and communication skills.
- A commitment to teamwork in a fast-paced, highly collaborative laboratory environment.
Some positions or sites may require that the incumbent be fully vaccinated against COVID-19. Proof of vaccination may be required.
Employment is contingent upon successful completion of a Public Trust-level background check, a requirement for this position under an active federal contract. The background check process may include, but is not limited to the following: (1) contacting your professional references; (2) verification of previous employment, education and credentials; (3) a criminal background check; (4) use/abuse of federally-controlled substances; and (5) a department of motor vehicle check. Candidates must be prepared to fully-complete any required background check questionnaire during initial onboarding.