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solid state nmr spectoscopist
2 months ago
Scientist IV
Duties & Responsibilities:
- Apply skill in solidstate
NMR (ss
NMR) spectroscopy to acquire and interpret (1D and 2D 1H, 19F, 13C, 15N, etc.) data for molecular structure elucidation. - A pply ss
NMR to characterize pharmaceutical materials such as particles, powders, and suspensions and to guide robust drug substance and drug product development. - Use
NMR expertise to evaluate and characterize a broad range of materials, including crystalline and noncrystalline small molecule APIs, biologics, excipients, drug product intermediates, and drug products. - Apply quantitative ss
NMR methods to measure components of APIs and drug products. - Use molecular modeling and predictive tools with technologies such as solution/solid state
NMR and Xray crystallography to enable 3D structural evaluation at the atomic and molecular level. - Ensure backup and retrieval of all ss
NMR data. - Plan and perform experiments with minimal supervision to provide investigative support of structural predictions.
- Remain current with relevant scientific literature and apply knowledge to the design, modification and implementation of new experiments.
- Write protocols, methods and technical reports; provide scientific interpretation of results with minimal guidance.
- Present at internal scientific meetings.
Skills:
Requirements:
- Background in use of solution
NMR for structure elucidation is highly desired. - Experience with solid state
NMR sample preparation, data acquisition and interpretation of multinuclear
NMR data is required. - Experience with implementing and trouble shooting ss
NMR experiments. - Experience changing Bruker ss
NMR probes is required. - Basic understanding of molecular structure, inter atomic distances, hydrogen bonding, torsion angle strain, hydrophobic and hydrophilic interactions.
- Experience in the application and interpretation of ss
NMR to study biological systems is a plus. - Understands the conceptual basis behind modern computational methods such as qmDFT, Monte Carlo methods, etc.
- Knowledgeable in the routine use of molecular modeling software (example: Gaussian, Schrodinger, Materials Studio suite, CCDC software )
- Familiar with use of HPC clusters, Linux environment and associated job submission programs.
- Experience collaborating with diverse teams and demonstrated ability to work independently and with minimal supervision.
- Experience with preparing and analyzing membrane protein samples is a plus.
- Excellent laboratory practices to ensure safety and sample integrity.
- Excellent oral and written communication skills, highly organized and efficient record keeping.
- Background in use of solution
NMR for structure elucidation is desired.
Education:
Master's Degree in Organic Chemistry or equivalent with 1-3 yrs. experience in the application of ss
NMR Spectroscopy to structurally characterize pharmaceutically relevant small molecules.
Required
Skills:
SPECTROSCOPY
NMR
ANALYTICAL INSTRUMENTATION
ANALYTICAL CHEMISTRY
Company DescriptionMaxis Clinical Sciences provides complete Solution for Clinical and Digital Services. Maxis Clinical Sciences has been recognized in the industry for years, and an integrated research competence center.
The company provides 24×7 delivery globally, with teams across the world's 3 largest continents - North America, Europe and Asia.
We operates with a problem-solving approach that believes in promoting genuine relationships & steady communication.It works as true clinical and digital competence center and provides services with 200 plus techno-functional, domain experts, each with 12+ years of average experience.
Our popular service niches that earned us global accolades are: clinical data management, clinical analytics, patient-centric technology enablement services, statistical analysis and reporting services, data anonymization services, RWD aggregation and curation services etc.
Company DescriptionMaxis Clinical Sciences provides complete Solution for Clinical and Digital Services. Maxis Clinical Sciences has been recognized in the industry for years, and an integrated research competence center.The company provides 24×7 delivery globally, with teams across the world's 3 largest continents - North America, Europe and Asia.
We operates with a problem-solving approach that believes in promoting genuine relationships & steady communication.It works as true clinical and digital competence center and provides services with 200 plus techno-functional, domain experts, each with 12+ years of average experience.
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Our popular service niches that earned us global accolades are: clinical data management, clinical analytics, patient-centric technology enablement services, statistical analysis and reporting services, data anonymization services, RWD aggregation and curation services etc.
