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Senior Scientist
1 month ago
Job Location: Cambridge ,MA
Job Duration: 24 Months+
Shift: – Mon – Fri, Business Hours
Job Description:
Scientist – in-vitro disease modelling
Genome Sciences department in MRL is looking for a motivated scientist to lead the identification and validation of new genetic targets for various cardiometabolic diseases including Type 2 Diabetes (T2D), Obesity, Atherosclerosis, Retinal diseases, and vascular diseases. This individual will play a pivotal role as a member of the discovery team, contributing to the development of innovative models for screening drug targets.
Job responsibilities:
• Establish stem cell-based in-vitro disease platforms.
• Design assays using high content imaging techniques to facilitate screening of small molecules and genetic modifications using CRISPR.
• Perform lab experiments, interpret data, and effectively communicate findings.
• Collaborate with cross-functional teams in therapeutic and functional areas.
• Maintain electronic lab notebook and sample inventories.
Qualifications:
Education requirements:
• BS with 5+ years of experience/Masters with 3+ years of experience/PHD with 1+ year of experience in a wet lab setting.
• Candidates with a background in muscle biology will be given preference.
Required experience and skills:
• Skilled in cell culturing and differentiation of stem cells into specific lineages.
• Experience with gene manipulation technologies such as CRISPR, siRNA, ASOs, lentivirus, and AAVs.
• Expertise in molecular biology techniques including RNA extraction, qPCR, ELISA/MSD, and ICC.
• Critical thinking with an ability to formulate experimental strategies.
• Effective in working independently and collaboratively within a team.
• Outstanding verbal and written communication skills.
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