Sr. Research Associate
5 days ago
Cambridge, MA
Full time, permanent role
100% onsite
Research Associate II/Senior Research Associate, Quality Control & Analytical Development
Notes:
Looking for 2 plus years CDMO experience
Will be stress testing protein assays for eventual tech transfer to CDMO.
Must have experience characterizing proteins/antibodies and developing assays using techniques such as SDS-PAGE, Western blot, protein quantitation, HPLC, ELISA; ideally for CRO/CDMO transfer
Looking for candidates with downstream process development/analytical development experience, not upstream or discovery.
Candidate should understand entire process development lifecycle in order to collaborate with downstream team and CDMO.
Willingness/ability to work in a cross-functional team environment, on a small team.
Role Overview:
We are seeking a passionate Research Associate II/Senior Research Associate to work in the Protein Engineering and Molecular Sciences Team to support analytical and biophysical QC of TCR bispecifics and MHC proteins as well as development of analytical assays for tech transfer to manufacturing. The ideal candidate will have hands-on experience in methods such as size exclusion HPLC, SDS-PAGE, DSF, ELISA and/or Octet/SPR. The selected candidate will work at the bench to QC TCR bispecifics and MHC proteins, conduct stability/developability assessments to prioritize therapeutic leads, and develop robust assays for tech transfer to manufacturing partners. This incumbent will be responsible for developing SOPs, generating biochemical and biophysical data, data analysis and presenting data to their manager and to the team in an effective and timely manner. Interested candidates should have strong organizational, interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross-functional team.
Key Responsibilities:
Analytical and biophysical QC of protein batches (analytical SEC, PAGE, DSF, Octet/SPR, ELISA).
Develop and document robust analytical assays for tech transfer to manufacturing partners.
Conduct comparability, developability and accelerated stability assessments of lead therapeutic molecules.
Capture primary data, establish and maintain SOPs, and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
Present data routinely to the Protein Sciences group and other multidisciplinary groups.
Qualifications/Experience:
BS/MS in Biochemistry, Biology, Bioengineering, Immunology, or a similar field.
2+ years of academic or biotech/pharma laboratory experience.
Experience with HPLC systems and with biochemical assays such as ELISA, SDS-PAGE and DSF.
Experience with Octet, SPR or flow cytometry a plus.
Strong organizational and communication skills along with excellent attention to details.
Enjoys working in a collaborative, fast-paced and quickly changing environment.
pay within this range will be commensurate with level of experience
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