Research Associate

4 days ago

Cambridge, United States BlueRock Therapeutics Full time
Who is BlueRock?
BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.
What Are We Doing?
Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit. We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients‘ lives.
BlueRock Therapeutics, Cambridge location is hiring a Research Associate II, In Vivo within the Immunology group. This position is responsible for hands-on in vivo work for mouse models and ex vivo tissue analysis in immunology. This is an outstanding opportunity for a talented and self-motivated person to contribute to cutting-edge cellular therapies to patients while gaining valuable career experience in translational Immunology.Responsibilities:
  • Support the execution of in vivo experiments in multiple mouse models across diverse therapeutic areas including inflammatory diseases, autoimmunity, transplantation, and neurology related diseases under guidance and supervision.
  • Animal manipulation (handling, i.p., i.v., s.c., and i.m. injections), sample collection, as well as tissue processing in compliance with IACUC protocols and animal welfare standards.
  • Analysis of blood and tissue samples using a variety of techniques, including flow cytometry, ELISA, Luminex and other molecular and cell biology techniques.
  • Execute efficacy, toxicity, biodistribution, and PK/PD in vivo studies under supervision.
  • Analyzing, reviewing, and presenting data within groups and across-functionally at department meetings.
  • Comply with standard laboratory practices and company policies, including electronic notebook and biosafety policies.
  • Maintain scientific curiosity and familiarity with relevant literature and cutting-edge technologies to advance research directions.
Minimum Requirements:
  • Bachelor‘s Degree in a relevant discipline with 2+ years of relevant experience, or Master‘s degree in a relevant discipline with industry experience preferred.
  • BS and MS in Immunology, Biology, Physiology, or related discipline is preferred.
  • Experience with in vivo mouse handling, with multiple routes of injection (i.p., i.v.,s.c.,i.m., etc) in murine models, as well as blood and tissue collection techniques. Experience in mouse models of inflammatory diseases, autoimmunity and humanized mice is preferred. Experience with stereotaxic intracranial injection is a plus.
  • Experience with characterization and assay of immune cell population and cytokines is desired, but not required (e.g., Multicolor FACS, Luminex, ELISA, etc.).
  • Experience of live-animal bioluminescent imaging and analysis, NGS and spatial analysis is desirable, but not required.
  • Experience with in vitro cell culture, passage and freeze.
  • A strong self-starter, independent thinker, with a strong attention to detail.
  • Ability to work productively in a fast-paced, team environment is required.
  • Effective communicator with excellent interpersonal and organizational skills is required.
  • Role requires individual to be onsite full time to conduct laboratory work
Other Relevant Information:
  • Candidate will be working in office, vivarium, and controlled laboratory environments.
  • Understanding and compliance to animal welfare standards is required.
  • Travel (national and international) may be required (

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