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Senior Scientist

4 months ago

San Mateo, United States Theery Full time

Principal/Senior Scientist, Proteomics


Duties:

  • Work with a multidisciplinary team of automation engineers, data scientist, software developers and clinical researchers to develop a large-scale multi-omics platform
  • Work closely with a bioinformatics team on the design, development and implementation of proteomics experiments to support assay and platform development
  • Develop novel metabolomics & lipidomics sample preparation and data collection methods that further internal biomarker discovery effort
  • Continually evaluate cutting technologies and, provide insights/strategies for the implementation of cutting-edge proteomics technologies and expertise to further multi-omics platform
  • Provide scientific thought leadership in the development and implementation of strategic and tactical plans aligned with overall business objectives
  • Communicate recent experimental results to an internal multidisciplinary team and externally through scientific presentations and peer-reviewed publications
  • Operate, maintain and troubleshoot a variety of new mass spectrometers
  • Manage and mentor a small team of scientists
  • Document results of analyses and investigations in a reproducible manner and communicate insights to both experts and non-experts


Requirements:

  • Ph.D. in biology, biochemistry or analytical chemistry with 5+ years relevant industry experience in mass spectrometry-based proteomics
  • Excellent skills in experimental design, implementation, troubleshooting and data interpretation
  • Broad knowledge of mass spectrometry-based protein quantification and identification strategies
  • Hands-on experience in the operation of QQQ, and HRMS instrumentation (e.g., Orbitrap, qTOF, IMS-TOF, etc.)
  • Significant hands-on experience with sample preparation (e.g. liquid-liquid extraction, SPE, etc.)
  • Deep experience in MS-based metabolomics & lipidomics data processing tools
  • Basic programming skills relevant to metabolomics & lipidomics data analysis (i.e. Python, R, etc.) is desirable
  • Demonstrated experience with multiple MS acquisition modalities (i.e. DIA, PRM, MRM, DDA, etc.)
  • Must work well in a small team setting, with ability to work independently and collaboratively while meeting deadlines
  • Highly organized, exceptional attention to detail and strong documentation skills
  • Excellent communications and presentation skills, as well as a desire to work across functional teams
  • Desire to focus on breakthroughs in an exciting, fast-paced startup environment