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Senior Research Associate
2 months ago
Duration: 12 Months Contract
Hybrid - The GDEPD department adheres to an 80% onsite requirement for all lab-based employees. This gives employees the flexibility to work at home 1 day per week.
Job Description:
The associate will join the LVV Platform Development team working on vector biology and molecular optimization initiatives intended to drive next-generation viral vector platform development. Specifically, in the pursuit of end-to-end assessment of Client technologies and approaches, the associate will seek to become highly proficient in downstream purification of lentiviral vectors, while gaining familiarity with LVV analytical methods and their interpretation in the context of LVV attributes and biology. The associate will also have the unique opportunity to be exposed to a wide range of highly Client molecular designs, and to work collaboratively with a range of different groups doing different types of LVV development.
Responsibilities:
Routine purification of LVV for platform fit assessment.
Execute and troubleshoot upstream and downstream process development experiments supporting next-generation LVV production.
Manage the flow of samples and data and perform analyses.
Assist in the design of experiments and interpretation of data.
Provide experimental design and executional support to team members in adjacent and related functions (e.g.
clinical development programs, high throughput process development, etc.).
Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities.
Actively participate and support lab maintenance and continuous improvement initiatives.
Maintain accurate and detailed laboratory notebook and documentation.
Summarize and present data in group meetings and contribute to group discussions and team strategy.
Author technical reports and study memos.
Experience:
STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset.
Experience with purification of biologics (mAbs, fc-fusion proteins) or viral vectors.
Hands on experience in biologics process development.
Independently motivated with ability to work in teams.
Ability to communicate clearly and concisely through oral presentation and technical writing.
Ability to leverage literature, internal and external resources to solve problems.
Skills:
Experience with downstream processes development e.g., chromatography, chromatography resin screens, filtration, depth filter screens, TFF development, TFF flux excursions, process-analytical technology (PAT).
Experience with chromatography operation.
Experience with harvest filtration operation of biologics and/or viral vectors.
Experience with tangential flow filtration (TFF) or ultrafiltration/diafiltration (UF/DF) operation.
Experience in the development of viral vectors (e.g., adeno-, retro-, lenti-), including successful transfer for GMP manufacturing.
Experience with AKTA chromatography skid operation.
Experience with tangential flow filtration or ultrafiltration/diafiltration operation.
Experience with depth filtration operation.
Experience with JMP for DoE design and analysis.
Experience with mammalian cell culture operation.
Education:
Degree in biological, biomedical, or chemical engineering, biochemistry, or bio-related field.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.
US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Recruiter Details:
Name: Sateesh
Email: podishetty@ustechsolutionsinc.com
Internal Id: 24-16285
