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Post-Doctoral Research Fellow

3 months ago


Seattle, Washington, United States Fred Hutchinson Cancer Center Full time

Fred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.

With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.

At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.

The Corey Lab is seeking a highly motivated post-doctoral research fellow to work with an interactive collaborative team of scientists investigating molecular and cellular mechanisms of local control of HSV-2 in genital tissue using various cutting-edge technologies. As a part of the Corey lab, Dr. Sholukh's research is focused on multifaceted analysis and characterization of humoral immune response to viral infections and vaccines with particular emphasis on recently discovered (Ford & Sholukh et al., J. Clin. Invest novel class of B cells, skin-resident antibody-secreting cells (ASCs), and their role in forming of local virus immune control. The mission of the Corey Lab is to make discoveries that lead to development of herpes virus vaccine and novel immunotherapies of viral infections including HIV.

Responsibilities

The successful applicant will utilize various single-cell RNA-seq and BCR-seq technologies, data analysis, spatial transcriptomic, as well as antibody discovery, characterization and engineering aiming to understand fundamental immunologic mechanisms of in-tissue HSV control. The other techniques involved will include protein cloning and purification, different types of functional and binding antibody assays, epitope mapping and passive immunization. The position will require independent research, to be eager to learn new technologies, and the ability to collaborate closely with computational biologists, biostatisticians and other colleagues.

Qualifications

MINIMUM QUALIFICATIONS:

  • MD and/or PhD in Biology, Immunology, Biochemistry, Virology or another relevant discipline.
  • Track record of productive research.
  • Excellent written and verbal communication skills are essential.

PREFERRED QUALIFICATIONS:

  • Experience in B cell biology, single-cell RNA-seq or phylogenetic analysis including knowledge of relevant programs in R and Python is strongly desired.

The annual base salary range for this position is from $67,728.00 to $100,000.00 and pay offered will be based on experience and qualifications. This position may be eligible for relocation assistance.