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Research Fellow in Cardiology

2 months ago


Seattle, Washington, United States UW Medicine Full time
Position Overview

A postdoctoral opportunity is available within the Division of Cardiology at UW Medicine, focusing on the investigation of mitochondria-containing extracellular vesicles (MitoEV) and their involvement in sterile inflammation linked to heart failure and type 2 diabetes.

Role Responsibilities

This full-time position entails a 12-month appointment, where the selected candidate will engage in:

  • Cell-Based Research (50%):
    • Creating gene-deletion monocyte lines utilizing CRISPR technology.
    • Conducting volume-metric flow analysis to measure MitoEV release.
    • Performing confocal and electron microscopy to examine subcellular structures.
    • Executing biochemical assays for functional and anatomical evaluations of mitochondria and lysosomes.
    • Assessing mitophagy and autophagy through live-cell imaging and flow analysis.
  • Mouse Model Development (50%):
    • Generating and maintaining gene-knockout mouse lines.
    • Administering isolated MitoEV via venous injection.
    • Conducting small animal nuclear imaging to assess tissue targeting of MitoEV.
    • Analyzing tissue samples for inflammation.
    • Performing trans-thoracic echocardiograms to evaluate left ventricular function.
Research Environment

UW Medicine offers a dynamic research setting in cardiovascular biology, complemented by the appealing lifestyle of the Pacific Northwest. Competitive salary packages are available, along with opportunities for postdoctoral fellowships.

Qualifications

The ideal candidate will possess a Ph.D. or equivalent in biological sciences, with a robust publication record, particularly in first-author contributions. Preference will be given to those with aspirations for an academic career.

Application Instructions

Interested candidates should submit a cover letter and CV, along with the contact information for three references through the designated application platform.

Equal Opportunity Statement

UW Medicine is committed to affirmative action and equal opportunity employment. All qualified applicants will be considered without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.