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Research Associate, Vector Biology
3 months ago
Affinia Therapeutics is an innovative gene therapy company with a vision to create a paradigm shift by broadening the reach of gene therapy to prevalent diseases.
Our proprietary Affinia Rationally-designed Therapies (ART) platform was created to address key efficacy, safety, and cost of goods limitations of conventional gene therapies.
We are backed by a strong syndicate of life science investors. Our purpose is to have a dramatic impact on the lives of patients around the world.You will play a key role in shaping our culture and embodying our values of integrity, passion, and teamwork. You will be working alongside the management team who has a track record of success in the industry. The pace of work is dynamic, fast, and fun.
We offer a competitive salary and benefits with the ability to make a difference.
Position Summary
Affinia Therapeutics is seeking an experienced scientist (job level will be commensurate with experience) to join our Vector Biology laboratory team.
You will be part of a team dedicated to advancing AAV-based gene therapies using your expertise in Next Generation Sequencing (NGS), molecular biology/cloning, and cell-based assays.
This is a lab-based, onsite role where you will actively contribute to capsid discovery and disease programs.The role is located at our state-of-the-art facility, in Waltham, MA, and reports to the Head of Vector Biology.
Primary Responsibilities
Be an integral member of our NGS platform, receiving and processing samples for sequencing using our Illumina and Nanopore devices
Create and execute cloning strategies to generate constructs that express Therapeutic Cargos such as proteins and artificial microRNAs
Independently perform cell-based assays to determine AAV functionality
Work cross-functionally with our Computational Biology and Process Science teams in these efforts
Write, prepare and present technical data, technical reports and standard operating procedures (SOPs) for internal use and tech transfer
Maintain an up-to-date electronic notebook, participate in meetings, prepare presentations and communicate to leadership as needed
Minimum Qualifications
4+ years of industry experience
Hands-on experience with techniques required to extract RNA/DNA from virus, mouse, non-human primate and mammalian cell culture models, and then process for NGS using Illumina Novaseq (amplicon-based) and Nanopore MinION devices
Hands-on experience with molecular biology techniques including plasmid cloning, DNA sequencing analysis, plasmid preparation, restriction digests, agarose gel electrophoresis, Gibson assembly
Hands-on experience with cell-based assays including cell culture and cell transfection/transduction, fluorescence-based readouts using plate readers or FACS, RNA/DNA extractions and qPCR/ddPCR, protein gels and Western blots
Excellent written and oral communications skills, including experience writing laboratory SOPs, protocols, and reports
Ability to organize and communicate scientific data to management and internal stakeholders
Ability to work independently to determine and acquire new methods and scientific knowledge
Strong collaboration skills
Prior AAV-related experience a plus
Ability to thrive in a fast-paced environment flexibly and collaboratively
Operate daily with Integrity, Teamwork, and Passion
EEO Statement:
Affinia Therapeutics is proud to be an equal opportunity workplace.
We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
If you have a disability or special need that requires accommodation, please let us know.#J-18808-Ljbffr
