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Life Science Research Professional 3 Research Scientist in Genetics

4 months ago

Stanford, United States Stanford University Full time

The Laboratories of Casey Gifford (Depts of Genetics and Pediatrics) and Jesse Engreit (Dept of Genetics) are seeking a Research Scientist (Life Science Research Professional 3) focusing on human and mouse genetics, genome editing, and genomics to lead a project to understand the genetic basis of congenital heart defects. The Gifford and Engreitz Laboratories are located in the Biomedical Innovations Building on the main campus at Stanford University and are members of the BASE Initiative in the Betty Irene Moore Children s Heart Center, a collaboration with Drs. Mark Skylar-Scott (Dept of Bioengineering) and Marlene Rabinovitch (Dept of Pediatrics).

Project overview:
DNA regulatory elements in the human genome, which harbor thousands of genetic risk variants for common and rare heart diseases and could reveal targets for therapeutics that aim to precisely tune cellular functions if only we could map the complex regulatory wiring that connects 2 million regulatory elements with 21,000 genes in thousands of cell types in the human body. We have recently developed new approaches that could enable mapping this regulatory wiring at massive scale (see Fulco et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et al. Nature 2021), and applied these and other approaches to understand the genetic basis of congenital heart defects (Gifford et al. Science 2019, Schricker et al. Nature 2019, Ameen et al. bioRxiv 2022). We have now identified enhancers that contain disease variants that affect risk for congenital heart defects, and aim to study the functions of these enhancers in mouse models and human cardiac organoids. These studies will ultimately help to uncover biological mechanisms of congenital heart defects, and help to guide diagnosis and treatment for children with heart disease. For information and recent work, see and

We are looking for creative and passionate people at any stage in their career (see other job postings). The Gifford and Engreitz Laboratories are located adjacent to one another and provide a dynamic, interdisciplinary workplace with unique access to cutting edge technologies and scientific thought, with the potential for widespread recognition of scientific contributions. We value a diversity of values, backgrounds, and approaches to solving problems.

The candidate for this position should have hands-on experience in mouse genetics, molecular biology, genomics, and cellular assay development; experience with quantitative data analysis; curiosity in research and creativity in problem-solving; strong interpersonal and collaboration skills; experience building or managing teams; outstanding verbal and written communication abilities; ability to adapt to and effectively manage changes in a fast paced and dynamic environment; and have a passion for science and sense of urgency to find new medicines to benefit patients.

In addition to submitting your application via the Stanford web portal, please email your CV and cover letter directly to Profs. Casey Gifford (. @stanford.edu) and Jesse Engreitz (. @stanford.edu)

Duties include:

Make fundamental discoveries about gene regulation and the genetics of cardiovascular disease.Together with PI and other lab members, design and execute scientific projects.Develop and apply strategies to study enhancers and genes in human cells and mouse models.Evaluate and recommend new emerging technologies, approaches, and problems.Train and collaborate with other lab members in experimental techniques, scientific design, and other skills.Design and lead independent projects.Collaborate with a team of experimentalists and computational biologists.Create scientifically rigorous visualizations, communications, and presentations of results.Contribute to generation of protocols, publications, and intellectual property.


• - Other duties may also be assigned.

DESIRED QUALIFICATIONS:

Ph.D. in Biology, Biochemistry, Biophysics, Genetics, Bioengineering, Developmental Biology, or related life science field is preferred. Highly motivated candidates of all levels are encouraged to apply.Expert in mouse genetics, with experience studying embryoic or heart development a plus.Experience in technology development, molecular biology, genomics, and cellular assay development.Experience with quantitative data analysis.Experience with CRISPR targeting ES/iPS cells or single-cell RNA-seq a plus.Curiosity in research and creativity in problem-solving.A great team member with strong interpersonal and collaboration skills.Outstanding verbal and written communication abilities.Ability to adapt to and effectively manage changes in a fast paced and dynamic environment.A passion for science and sense of urgency to find new medicines to benefit patients.

EDUCATION & EXPERIENCE (REQUIRED):

Bachelor's degree in related scientific field and four years of relevant work experience; or Master s degree in a related scientific field and two years relevant experience; or PhD in related science field.

KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):

Comprehensive understanding of scientific principles.Expert level knowledge and skills in field of science related to research project.General computer skills and experience with databases and scientific applicationsStrong analytical skills and excellent judgment. Ability to work under deadlines with general guidance is essential. Excellent organizational skills and demonstrated ability to complete detailed work accurately.Developing project management skills.

PHYSICAL REQUIREMENTS
• :

Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds. Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts. Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls. Must have correctible vision to perform duties of the job.Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.Ability to lift heavy objects weighing up to 50 pounds.Position may require repetitive motion.


• - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

WORKING CONDITIONS: