Biomarker Scientist

2 months ago

Cambridge, United States QurAlis Full time

ABOUT THE COMPANY 

At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative diseases. Founded by an internationally recognized team of neurodegenerative biologists from Harvard Medical School and Harvard University, QurAlis is a clinical-stage biotechnology company advancing a pipeline with therapeutic candidates that target specific components of ALS and FTD pathology and defined patient populations based on both disease-causing genetic mutation(s) and clinical biomarkers.   


Summary of Position: 

 

QurAlis is seeking a highly motivated Biomarker Scientist to support and execute its CNS Biomarker discovery program.  The Biomarker Scientist will develop translational strategies for novel therapeutics to assess pharmacodynamics, patient selection criteria, and mechanism of action. The Biomarker Scientist will work closely with the QurAlis scientific and management teams to perform and manage studies in a high quality and scientifically rigorous fashion.   

 

Primary Job Responsibilities : 

 

  • Independently plan and execute experiments, and contribute high level scientific neurodegeneration pathways expertise 
  • Assay development for customized, highly sensitive RNA and protein quantification 
  • Design and implement discovery plans and oversee the execution 
  • Analyze data, interpret results, identify problems, and develop creative troubleshooting plans 
  • Identification of contract research vendors and management of contract research studies  
  • Proactively review the scientific field to identify and share new scientific findings, ideas, and methods with other scientists at QurAlis 
  • Collaborate with clinical experts at QurAlis to translate biomarker plan 
  • Communicate effectively across the organization with translational medicine, clinical development, and discovery teams. 
  • Present research findings internally and externally at scientific meetings/conferences 

 

Minimum Qualifications Required:

 

  • A PhD in cell biology, molecular biology, biochemistry, neuroscience, or a related field 
  • 3-5 years relevant experience in academic and/or industry (biotech or pharma) settings including experience in neurodegenerative disease mechanisms, disease modeling, drug discovery or assay development. Previous biomarker development experience is preferred but not required. 
  • Proven track record of scientific excellence as evidenced by high impact, peer reviewed publications 
  • Proactive, willingness to contribute to bench work in the lab 
  • Ability to work independently and collaboratively in cross-functional teams 
  • Strong organizational skills, work ethic, and high-level motivation 
  • Capacity to be highly productive in a dynamic and fast-paced work environment 
  • Comfortable working in or leading matrix team 
  • Excellent oral, written and interpersonal communication skills 
  • Authorized to work legally in the United States 

 

Additional Qualifications Desired: 

  • Hands-on experience developing and troubleshooting customized RNA or protein high throughput assays 
  • Expertise in extracellular vesicle isolation methods from biofluids or cell culture media 
  • Previous experience managing multiple outsourced projects while maintaining timelines and milestones
  • Experience progressing an assay from development to analytical validation   

  • Biomarker Scientist

    3 months ago

    cambridge, United States QurAlis Full time

    ABOUT THE COMPANY At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative...

  • Biomarker Scientist

    2 months ago

    cambridge, United States QurAlis Full time

    ABOUT THE COMPANY At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative...

  • Biomarker Researcher

    3 weeks ago

    Cambridge, Massachusetts, United States QurAlis Full time

    About QurAlisWe are a clinical-stage biotechnology company advancing a pipeline with therapeutic candidates that target specific components of ALS and FTD pathology and defined patient populations based on both disease-causing genetic mutation(s) and clinical biomarkers.Job SummaryWe are seeking a highly motivated Biomarker Scientist to support and execute...

  • Senior Research Scientist, Biomarker Discovery and Data Science

    4 weeks ago

    Cambridge, Massachusetts, United States Flagship Pioneering Full time

    About the Role:We are seeking a highly skilled Senior Research Scientist to join our team at Flagship Pioneering. As a Senior Research Scientist, you will be responsible for developing and applying computational skills to understand complex biological systems and their relationship to clinical state changes.Key Responsibilities:Design and implement novel...

  • Associate Director/Sr. Principal Scientist of Translational Medicine

    4 weeks ago

    Cambridge, Massachusetts, United States Bristol Myers Squibb Full time

    Transforming Patients' Lives through ScienceBristol Myers Squibb is a leading pharmaceutical company dedicated to transforming patients' lives through science. We are seeking a highly skilled and experienced Associate Director/Sr. Principal Scientist of Translational Medicine to join our team.The successful candidate will be responsible for leading...

  • Co-op, Analytical Scientist in Biomarker Research

    4 weeks ago

    Cambridge, Massachusetts, United States Biogen Full time

    Job DescriptionThis role is for a 6-month student position from January to June 2025. Resume review begins in October 2024.Biomarkers are measurements that can help predict disease progression, describe a drug's mechanism of action, or identify disease risk factors. Application of biomarkers to clinical studies allows for teams to make efficient, data-driven...

  • Co-op Researcher in Fluid Biomarkers

    3 weeks ago

    Cambridge, Massachusetts, United States Biogen Full time

    Biogen's Translational Medicine Fluid Biomarkers group is seeking a highly motivated co-op to join a dynamic team engaged in the discovery and development of novel biomarkers to support research efforts and possible implementation in preclinical and clinical studies.The role will be predominantly laboratory based (80-90%) and will work closely with other...

  • Co-op Research Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Biogen Full time

    Job SummaryWe are seeking a highly motivated Co-op Research Scientist to join our dynamic team in the Fluid Biomarkers group at Biogen. The successful candidate will be responsible for identifying, evaluating, and characterizing relevant biomarkers in support of multiple programs across the company.Key ResponsibilitiesSearch literature and databases to...

  • Senior Scientist/Principal Scientist, Biomarker Discovery and Data Science

    4 months ago

    Cambridge, United States Flagship Pioneering Full time

    Company Summary: Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as > 95% of global healthcare costs are spent on treating rather than preventing...

  • Senior Neurodegeneration Research Scientist

    2 weeks ago

    Cambridge, Massachusetts, United States QurAlis Full time

    About the CompanyAt QurAlis, we are a clinical-stage biotechnology company pioneering precision medicines for neurodegenerative diseases. Our team of internationally recognized neurodegenerative biologists from Harvard Medical School and Harvard University works with a relentless pursuit of knowledge and a precise attention to craft to discover and develop...

  • Senior Director of Translational Medicine

    4 weeks ago

    Cambridge, Massachusetts, United States Astellas Pharma Full time

    Job SummaryThe Senior Director of Translational Medicine will lead the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area. This position is responsible for developing the translational strategies for Astellas assets, taking accountability for day-to-day delivery aligned with approved...

  • Clinical Research Assistant

    4 weeks ago

    Cambridge, Massachusetts, United States Prime Medicine Full time

    Job Summary:Prime Medicine is seeking a highly motivated and detail-oriented Clinical Research Assistant to join our team. As a Clinical Research Assistant, you will play a key role in advancing biomarker strategies for early development and clinical stage programs at Prime Medicine. You will gain hands-on experience in various aspects of biomarker research,...

  • Senior Translational Medicine Leader

    3 weeks ago

    Cambridge, Massachusetts, United States Astellas Pharma Full time

    About the RoleThe Group Leader, Translational Medicine and Science will lead the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area. This position is responsible for developing the translational strategies for Astellas assets, taking accountability for day-to-day delivery aligned with approved...

  • Senior Translational Medicine Leader

    4 weeks ago

    Cambridge, Massachusetts, United States Astellas Pharma Full time

    About the RoleWe are seeking a highly experienced and skilled Group Leader, Translational Medicine to join our team at Astellas Pharma. In this role, you will be responsible for leading the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area.Key ResponsibilitiesLead a team of Translational...

  • Director, Translation Imaging Lead

    2 days ago

    cambridge, United States Bayer Full time

    At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...

  • Senior Data Management Specialist

    4 weeks ago

    Cambridge, Massachusetts, United States Novartis International AG Full time

    Job OverviewThe Biomarker Development group at Novartis Bio Medical Research seeks a Senior Scientist, Imaging Data Management in our Clinical Imaging & Analytics team.This role aims to execute our clinical imaging data strategy to prospectively build raw data.Key ResponsibilitiesExecute clinical imaging data strategyBuild raw dataProspectively manage...

  • Director, Translation Imaging Lead

    38 minutes ago

    Cambridge, United States Bayer Full time

    Bayer Director, Translation Imaging Lead - Cambridge, MassachusettsAt Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique...

  • Biological Sciences Expert

    3 weeks ago

    Cambridge, Massachusetts, United States Beacon Hill Life Sciences - Boston Full time

    Beacon Hill Life Sciences - Boston seeks a high-caliber Senior Scientist II/III to join its Biological Sciences oncology drug discovery team. Report to a Senior Principal Investigator, Biological Sciences, and work onsite at the research facility in Lawrence, Kansas. Responsibilities include designing and conducting rigorous experiments, conceiving and...

  • Contractor, Senior Scientist II/III, Biological Sciences

    2 months ago

    Cambridge, United States Beacon Hill Life Sciences - Boston Full time

    Job DescriptionJob DescriptionThe Role:We are seeking a talented, collaborative, highly motivated and self-driven individual to join our Biological Sciences oncology drug discovery group.  This Senior Scientist II/III level role requires working closely with the wider multidiscplinary research team to discover new small molecule therapeutics for the...

  • Senior Bioinformatics Researcher

    3 weeks ago

    Cambridge, Massachusetts, United States Catalytic Data Science Full time

    Job Title: Sr. Bioinformatics ScientistAbout Catalytic Data Science:Catalytic Data Science is a pioneering cloud platform designed to integrate vast scientific resources, data, and analytical tools in a secure and scalable environment. This platform enables R&D teams to work more collaboratively, improving productivity company-wide, and helping teams achieve...