Biomarker Scientist
3 months ago
ABOUT THE COMPANY
At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative diseases. Founded by an internationally recognized team of neurodegenerative biologists from Harvard Medical School and Harvard University, QurAlis is a clinical-stage biotechnology company advancing a pipeline with therapeutic candidates that target specific components of ALS and FTD pathology and defined patient populations based on both disease-causing genetic mutation(s) and clinical biomarkers.
Summary of Position:
QurAlis is seeking a highly motivated Biomarker Scientist to support and execute its CNS Biomarker discovery program. The Biomarker Scientist will develop translational strategies for novel therapeutics to assess pharmacodynamics, patient selection criteria, and mechanism of action. The Biomarker Scientist will work closely with the QurAlis scientific and management teams to perform and manage studies in a high quality and scientifically rigorous fashion.
Primary Job Responsibilities :
- Independently plan and execute experiments, and contribute high level scientific neurodegeneration pathways expertise
- Assay development for customized, highly sensitive RNA and protein quantification
- Design and implement discovery plans and oversee the execution
- Analyze data, interpret results, identify problems, and develop creative troubleshooting plans
- Identification of contract research vendors and management of contract research studies
- Proactively review the scientific field to identify and share new scientific findings, ideas, and methods with other scientists at QurAlis
- Collaborate with clinical experts at QurAlis to translate biomarker plan
- Communicate effectively across the organization with translational medicine, clinical development, and discovery teams.
- Present research findings internally and externally at scientific meetings/conferences
Minimum Qualifications Required:
- A PhD in cell biology, molecular biology, biochemistry, neuroscience, or a related field
- 3-5 years relevant experience in academic and/or industry (biotech or pharma) settings including experience in neurodegenerative disease mechanisms, disease modeling, drug discovery or assay development. Previous biomarker development experience is preferred but not required.
- Proven track record of scientific excellence as evidenced by high impact, peer reviewed publications
- Proactive, willingness to contribute to bench work in the lab
- Ability to work independently and collaboratively in cross-functional teams
- Strong organizational skills, work ethic, and high-level motivation
- Capacity to be highly productive in a dynamic and fast-paced work environment
- Comfortable working in or leading matrix team
- Excellent oral, written and interpersonal communication skills
- Authorized to work legally in the United States
Additional Qualifications Desired:
- Hands-on experience developing and troubleshooting customized RNA or protein high throughput assays
- Expertise in extracellular vesicle isolation methods from biofluids or cell culture media
- Previous experience managing multiple outsourced projects while maintaining timelines and milestones
- Experience progressing an assay from development to analytical validation
-
Biomarker Scientist
2 months ago
cambridge, United States QurAlis Full timeABOUT THE COMPANY At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative...
-
Biomarker Scientist
5 months ago
Cambridge, United States QurAlis Full timeABOUT THE COMPANY At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative...
-
Biomarker Scientist
2 months ago
Cambridge, United States QurAlis Full timeABOUT THE COMPANY At QurAlis, we are neuro pioneers on a quest to cure. We work with a relentless pursuit of knowledge, a precise attention to craft, and an optimistic mindset to discover and develop effective precision medicines that will alter the trajectory of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerative...
-
Biomarker Researcher
4 weeks ago
Cambridge, Massachusetts, United States QurAlis Full timeAbout QurAlisWe are a clinical-stage biotechnology company advancing a pipeline with therapeutic candidates that target specific components of ALS and FTD pathology and defined patient populations based on both disease-causing genetic mutation(s) and clinical biomarkers.Job SummaryWe are seeking a highly motivated Biomarker Scientist to support and execute...
-
Co-op Researcher in Fluid Biomarkers
4 weeks ago
Cambridge, Massachusetts, United States Biogen Full timeBiogen's Translational Medicine Fluid Biomarkers group is seeking a highly motivated co-op to join a dynamic team engaged in the discovery and development of novel biomarkers to support research efforts and possible implementation in preclinical and clinical studies.The role will be predominantly laboratory based (80-90%) and will work closely with other...
-
Co-op Research Scientist
1 month ago
Cambridge, Massachusetts, United States Biogen Full timeJob SummaryWe are seeking a highly motivated Co-op Research Scientist to join our dynamic team in the Fluid Biomarkers group at Biogen. The successful candidate will be responsible for identifying, evaluating, and characterizing relevant biomarkers in support of multiple programs across the company.Key ResponsibilitiesSearch literature and databases to...
-
Cambridge, United States Flagship Pioneering Full timeCompany Summary: Each day, the lives of more than 2 billion people across the globe are impacted by chronic diseases. Moreover, the economic burden on society of treating chronic disease is spinning out of control. Today, this dire situation appears unlikely to change as > 95% of global healthcare costs are spent on treating rather than preventing...
-
Senior Neurodegeneration Research Scientist
3 weeks ago
Cambridge, Massachusetts, United States QurAlis Full timeAbout the CompanyAt QurAlis, we are a clinical-stage biotechnology company pioneering precision medicines for neurodegenerative diseases. Our team of internationally recognized neurodegenerative biologists from Harvard Medical School and Harvard University works with a relentless pursuit of knowledge and a precise attention to craft to discover and develop...
-
Senior Director of Translational Medicine
1 month ago
Cambridge, Massachusetts, United States Astellas Pharma Full timeJob SummaryThe Senior Director of Translational Medicine will lead the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area. This position is responsible for developing the translational strategies for Astellas assets, taking accountability for day-to-day delivery aligned with approved...
-
Senior Translational Medicine Leader
4 weeks ago
Cambridge, Massachusetts, United States Astellas Pharma Full timeAbout the RoleThe Group Leader, Translational Medicine and Science will lead the development and implementation of the Translational Medicine strategy within a defined disease or primary focus area. This position is responsible for developing the translational strategies for Astellas assets, taking accountability for day-to-day delivery aligned with approved...
-
Director, Translation Imaging Lead
6 days ago
cambridge, United States Bayer Full timeAt Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
-
Director, Translation Imaging Lead
4 days ago
Cambridge, United States Bayer Full timeBayer Director, Translation Imaging Lead - Cambridge, MassachusettsAt Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where 'Health for all Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique...
-
Biological Sciences Expert
4 weeks ago
Cambridge, Massachusetts, United States Beacon Hill Life Sciences - Boston Full timeBeacon Hill Life Sciences - Boston seeks a high-caliber Senior Scientist II/III to join its Biological Sciences oncology drug discovery team. Report to a Senior Principal Investigator, Biological Sciences, and work onsite at the research facility in Lawrence, Kansas. Responsibilities include designing and conducting rigorous experiments, conceiving and...
-
Cambridge, United States Beacon Hill Life Sciences - Boston Full timeJob DescriptionJob DescriptionThe Role:We are seeking a talented, collaborative, highly motivated and self-driven individual to join our Biological Sciences oncology drug discovery group. This Senior Scientist II/III level role requires working closely with the wider multidiscplinary research team to discover new small molecule therapeutics for the...
-
Senior Bioinformatics Researcher
4 weeks ago
Cambridge, Massachusetts, United States Catalytic Data Science Full timeJob Title: Sr. Bioinformatics ScientistAbout Catalytic Data Science:Catalytic Data Science is a pioneering cloud platform designed to integrate vast scientific resources, data, and analytical tools in a secure and scalable environment. This platform enables R&D teams to work more collaboratively, improving productivity company-wide, and helping teams achieve...
-
Senior Translational Medicine Expert
3 weeks ago
Cambridge, Massachusetts, United States Astellas Pharma Full timeAbout the RoleAstellas Pharma Inc. is a pharmaceutical company that conducts business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families.We are seeking a Senior Translational Medicine Expert to lead the development and implementation of the...
-
Associate Director/Director, Precision Oncology
4 weeks ago
Cambridge, Massachusetts, United States Flagship Ventures Full timeAbout the Role:Flagship Pioneering is seeking a talented and highly motivated Associate Director/Director Oncology to play a vital role in the company's efforts to progress lead candidates to IND and early clinical studies.The ideal candidate will be responsible for the translational validation of discovery platform targets in cell-based and disease-relevant...
-
Vice President, Translational Biology
3 weeks ago
Cambridge, United States Orbital Therapeutics Full timePosition Summary: Orbital is seeking a Vice President of Translational Biology with expertise in vaccines and autoimmunity. Reporting to the CSO, the candidate is expected to lead the areas of the company's therapeutic effort. The CSO, the candidate will supervise, motivate, and grow the research teams. They are expected to lead, manage, and analyze...
-
Cambridge, Massachusetts, United States Moderna Full timeAbout the RoleModerna is seeking a highly skilled and strategic Director of Shared Antigen Cancer Vaccines Research to join our Cancer Vaccines Research team, focusing on early pipeline programs. The Director will lead the early discovery and preclinical validation of shared antigen cancer vaccine candidates, overseeing the translation of innovative...
-
Associate Director, DMPK
2 weeks ago
Cambridge, United States Atavistik Bio Full timeCompany Summary: Atavistik Bio is focused on unlocking hidden functional pockets to discover transformative allosteric precision therapeutics to address serious unmet patient needs. By integrating our propriety screening technology using the body's natural regulators, with our powerful AI-enabled drug discovery platform, we are able to efficiently identify...