Peptide Synthesis Research Associate

1 week ago

Cambridge, United States Stealth Mode Biotech Full time

This Stealth Mode Company is a top-tier venture backed, privately held biotechnology company on a mission to create "a new modality to end all modalities". The team is aspiring to drastically scale up and change the trajectory of drug discovery by tackling the biggest challenges of existing modalities, and applying the platform to targets with the highest impact for patients. The Company is co-founded by a seasoned entrepreneur with a track record of establishing successful biotech ventures, both public and private, alongside another co-founder who formerly served as President of R&D for a large pharmaceutical company.


Overview

We are seeking a senior research associate for our Cambridge site with expertise in peptide synthesis to support the chemistry platform.


Responsibilities

  • Program, operate and troubleshoot automated parallel peptide synthesizers,
  • Perform synthetic modifications of peptides.
  • Program and operate analytical LC/MS, FLASH and preparative HPLC instruments to purify polypeptides and confirm their structure.
  • Develop protocols and methodologies for the synthesis modification and purification of synthetic peptides.
  • Diligently record and analyze experimental plans and complex data sets.


Required Qualifications

  • BA/BS or MSc degree in organic chemistry including solid-phase peptide synthesis (SPPS)
  • Knowledge and appreciation of laboratory safety procedures.
  • The successful candidate should be self-motivated, enjoy working in a fast-paced dynamic team environment, and be inspired to develop and apply new technologies to advance projects efficiently.
  • Excellent written, organizational and documentation skills. Ability to communicate progress effectively with colleagues across several scientific disciplines and managers.


Preferred Qualifications

  • 3+ years of research experience in the synthesis, purification and QC of a wide range of peptides containing standard and nonstandard amino acids.
  • Experience in the synthesis of peptide libraries.
  • Experience in advanced analytical techniques such as NMR, UV-VIS, FTIR
  • Experience with FPLC purification of proteins
  • May have experience with recombinant protein expression and purification

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