Senior Research Associate, Oligonucleotide Process Development
2 weeks ago
Why Join Intellia?
Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.
Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.
We wantall ofour people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.
How You Will Achieve More with Intellia:
This is a hands-on role in Oligonucleotide (sgRNA) process development for CRISPR/Cas 9 with the opportunity to support Intellia’s development pipeline for generating curative genome editing therapies. Within the Oligonucleotide and Small Molecule Process Development team, you will perform a variety of research experiments including synthesis, deprotection, desalting, and purification of oligonucleotides (sgRNA and other modalities). You will play a key role in advancing Intellia’s PD capabilities by:
Performing process parameter and condition screening for Intellia’s current and next generation oligonucleotide processes. Prepare and conduct solid phase oligonucleotide syntheses (AKTA Oligopilot, Oligosynt) at bench and process scales.
Synthesize sgRNA strands to inform candidate selection and evaluate manufacturability at feasibility stage.
Assist in developing downstream processes including ultrafiltration and purification of oligonucleotide products.
Perform basic lab tasks such as reagent and buffer preparation and chemical handling.
Conduct and analyze in-process tests (HPLC, UV-Vis) to evaluate process performance.
Aid in maintaining lab instruments such as AKTA synthesizers, purifiers, and HPLCs
Work cross-functionally with representatives of chemistry and analytical groups.
Plan and execute on sets of experiments (upstream focus)
Present results and conclusions of research to the broader PD/MSAT team.
Document research and proceduralize workflows and ways of operating as needed. Maintain electronic notebook, Lab SOPs, and chemical inventory.
About You:
Degree in Chemistry, Biochemistry, Biotechnology or related field with 2-5+ years (BS) or 0-2+ years (MS) of general laboratory experience.
Experience with solid-phase oligonucleotide synthesis, chromatographic purification as well as general analytical techniques used for the analysis of DNA/RNA oligonucleotides is a plus.
Experience working with synthetic oligonucleotides in an industrial setting is preferred.
Meet Your Future Team:
The Oligonucleotide and Small Molecule Process Sciences Team is an experienced, highly motivated, and lively group, with an innate curiosity to learn and improve. The respective team is focused on various critical activities with Technical Operations (CMC), including sgRNA and lipid manufacturing/process development. While a growing team of currently about 10 team members, you will interface with the broader Process and Analytical Development (PAD) team.
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Covid-19 Vaccination Policy:All Intellia employees, regardless of work location, are expected to follow all applicable federal, state, and local public health regulations and guidelines, and are strongly encouraged to follow all public health recommendations, including being vaccinated for COVID-19.
EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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