Senior Scientist, Discovery Chemistry

2 days ago

Boston, United States Monte Rosa Therapeutics Full time

Senior Scientist, Discovery Chemistry - MGD

Location : Boston MA


Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented medicinal chemist who is eager to discover molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable.

This position plays a key role in contributing to the development of our growing portfolio and will have a crucial impact at the forefront of drug discovery. The successful candidate should have strong interest in early-stage drug discovery, prior experience in HTS data analysis, hit follow-up as well as utilizing state-of-the-art medicinal chemistry knowledge up to the Lead Identification phase.


Principal Duties and Key Responsibilities

 Analyze High Throughput Screening (HTS) output with the goal of identifying promising starting points for hit generation chemistry from our growing MGD library.

 Serve as chemistry project lead against multiple early-stage projects.

 Develop hit follow up and lead generation strategy for discovery targets in collaboration with discovery scientists.

 Create structure activity relationship driven hypotheses for follow-up experiments to probe target engagement in hit validation.

 Provide tool compounds and contribute to target validation efforts as member of a cross-functional discovery team.

 Provide chemistry progressability assessments for early targets.

 Familiarity with key concepts and optimization strategies in medicinal chemistry including a clear understanding of ADME properties.

 Efficient and timely execution of compound syntheses through our CRO network, by devising efficient synthetic routes.

 Collaborate with external research partners.

 Communicate scientific findings and project updates to senior leadership and governance.

 Summarize and publish findings in manuscripts and patents when appropriate.



Job Requirements

 PhD in synthetic organic /medicinal chemistry or equivalent experience with a history of applicable publications in small molecule drug discovery.

 4 to 8 years of relevant professional experience in hit and lead generation chemistry.

 Deep experience of High Throughput Screening analysis and follow-up.

 Familiarity with early stages of pre-clinical research in drug discovery.

 High level of proficiency with databases, data analysis and visualization tools (e.g. Spotfire, D360, CDD, Maestro, Pymol).

 Proficiency in complex molecule synthesis and/or synthetic method development experience.

 Needs to be highly effective in cross-functional and cross-site teams.

 Experience of collaborating with CROs is essential.

 Excellent written and oral communication skills.


Interested candidates should forward CV and cover letter to careers-us@monterosatx.com



Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology, and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug.



To learn more about MRTx, visit www.monterosatx.com

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