Neuroimmunology Scientist, Research

4 months ago

Cambridge, United States Biogen Full time

About This Role

The Neurobiology Research Unit within the Rare Disease and Neurology research units at Biogen is seeking a highly skilled and dedicated individual with experience in neuroimmunology and neuroscience. This position will offer a unique opportunity to gain mechanistic understanding of interactions between cells of the immune system and central nervous system (CNS) under inflammatory conditions with new hypotheses generated from extensive analysis of single cell transcriptomics data of multiple neurodegenerative diseases followed by experimental validation using state of the art co-culture systems of human ipsc derived glial and neuronal cells.

Job Description

The Neurobiology Research Unit within the Rare Disease and Neurology Department at Biogen is a multi-disciplinary team investigating shared and disease-specific mechanisms of chronic inflammation and dysfunctional myelination in neurodegenerative diseases including multiple sclerosis, alzheimer’s disease and amyotrophic lateral sclerosis. Our mission is the development of novel therapeutics to improve the life of patients. You will be joining a team focused on identifying new targets through extensive analyses of single cell genomics studies of human brain tissues from MS, AD and ALS and from multi-omics characterization of in vitro and in vivo model systems of neuroimmunological diseases. The candidate will closely work with multiple groups across the research organization to design and execute research projects The work will involve a wide array of in vitro, in vivo, and analytical techniques using cellular and molecular approaches, and is expected to advance projects towards clinical development.

Responsibilities

Develop creative and innovative hypothesis and research plans to gain insights into disease relevant neuroinflammation phenotypes. Design, develop, and perform experiments to support scientific activities and project goals involving iPSC derived glial cells, co-culture, organoids, humanized in vivo models, and biochemical assays. Plan and conduct in vitro and in vivo studies, and analytics with particular emphasis on deep phenotyping to unveil novel neurodegenerative disease mechanisms. Prepare, review, and deliver scientific presentations for internal and external use. Build strong collaborations across the Research organization at Biogen and become a key member of a cross-research unit. Write reports, manuscripts and generate data packages supporting model development and drug candidate advancement.

Qualifications

Ph.D. in immunology, neuroscience, cell biology, or related disciplines, and 0-2 years of postdoctoral experience in academic or industry settings A record of relevant, high-quality publications Strong oral and written communication skills Experience with cell culture of primary CNS cells, flow cytometry, fluorescence microscopy, and/or molecular biology.

Additional experience desired

In vivo technical skills including dosing, aseptic techniques, tissue collection, and immunohistochemistry.

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

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