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Lead Scientist in Protein Purification
2 months ago
Job Title: Senior Scientist, Protein Purification & Expression
Location: Canton MA
About Pledge Therapeutics:
Pledge Therapeutics is a pioneering start-up committed to enhancing treatments in immunology, oncology, and virology. Our mission is to create innovative therapies that significantly improve patient outcomes. Utilizing our cutting-edge discovery platform, we have successfully developed high-quality, preclinical drug candidates targeting multiple promising drug pathways that have the potential to revolutionize current treatment methods.
Job Overview:
We are in search of a passionate and proficient scientist to spearhead protein purification, production, and characterization initiatives within our Rapid Response Group (RRG), a dedicated team in our Discovery Division. The RRG employs a hands-on, mission-driven strategy, engaging in high-impact projects to create essential tools, methodologies, and data that bolster our therapeutic programs. The ideal candidate will play a pivotal role in this distinguished team, advancing research on protein targets and therapeutic innovation. This position is vital to our R&D objectives, directly impacting our success by addressing protein-related challenges and facilitating the transition of groundbreaking discoveries into viable therapeutics.
Key Responsibilities:
- Design and refine protein expression systems, emphasizing baculovirus (insect cell) and/or mammalian systems, while performing sub-cloning as necessary to support these initiatives.
- Develop and implement innovative purification protocols to tackle technical challenges, drawing on a comprehensive understanding of molecular biology and biochemistry.
- Diagnose and enhance protein expression and purification strategies, ensuring high-quality protein production through advanced chromatographic and filtration techniques.
- Evaluate experimental data, assist in scale-up processes, and drive ongoing improvements while adhering to timelines in a dynamic, fast-paced setting.
- Collaborate across various functions with immuno-oncology, virology, and structural biology teams, sharing expertise to improve our capacity to work with a diverse array of proteins.
Qualifications:
- PhD in Biochemistry, Cell Biology, or a related discipline; outstanding MS candidates may be considered.
- 5-7 years of pertinent experience in a dynamic, fast-paced environment.
- Proficiency in construct design, sub-cloning, and protein purification, with experience covering the entire protein production pipeline, from gene design to characterization.
- Extensive expertise and practical experience with various protein expression systems, particularly baculovirus and/or mammalian expression, demonstrated by a history of work across different protein classes.
- Experience in purifying biologics using techniques such as affinity chromatography (e.g., Protein A/G/L, Ni-NTA), ion exchange, size exclusion, and hydrophobic interaction chromatography.
- Skilled in analytical techniques such as SDS-PAGE, HPLC or UHPLC, and other relevant analytical methods.
- Exceptional troubleshooting abilities, strong analytical skills, meticulous attention to detail, and outstanding organizational capabilities.
- High level of independence, intellectual capacity, and initiative.
- Strong work ethic and adaptability, with the ability to multitask and maintain a positive attitude as R&D priorities evolve.
Job Type: Full-time, Work Permit, Equal Opportunity Employment.
