X-Ray Crystallographer

We are seeking a highly skilled X-Ray Crystallographer to join our team at Pledge Therapeutics. As a key member of our research team, you will be responsible for solving crystal structures of key targets/molecules, including protein crystallography, initial screening, crystal quality optimization, data collection, and structure determination.

• Leverage crystallography expertise to solve crystal structures of key targets/molecules.
• Work cross-functionally with IO/Virology teams to produce high-quality proteins, including designing methodology and performing purification.
• Collaborate with biologists, biophysicists, biochemists, structural biologists, and medicinal chemists to develop comprehensive approaches to ensure target viability and address specific project needs.
• Establish protocols to characterize target proteins for small molecule interactions.

• Master/PhD degree in Structural Biology/Protein Biochemistry.
• 35 years of work experience as a bench scientist in industry (e.g. biotech/pharma).
• Experience in protein purification for different expression systems using multiple techniques.
• Preference will be given to candidates with direct experience in enzymology and crystallization techniques (cocrystallization, seeding, cross-seeding, soaking, harvesting, and freezing).
• Familiarity with chemistry and protein computational techniques.
• Champion a can-do attitude and flexibility to adjust as R&D priorities shift.