Senior Process Development Associate, Downstream

3 weeks ago


South San Francisco California, United States Encoded Therapeutics Full time
Job Summary

Encoded Therapeutics is seeking a highly skilled Senior Process Development Associate to join our Downstream Process Development group. As a key member of our team, you will be responsible for executing purification process development studies and purifying samples supporting upstream PD.

Key Responsibilities
  • Develop and execute bench-scale unit operations for rAAV purification, including chromatography, depth filtration, tangential flow-filtration, and viral filtration.
  • Utilize analytical methods, including ddPCR, ELISA, Refyn, Picogreen, Alkaline gel, CE-SDS, and SEC-HPLC.
  • Analyze, interpret, and present process performance and product quality data.
  • Maintain accurate records of all work performed in an electronic laboratory notebook.
  • Contribute to authoring and reviewing technical reports and standard operating procedures.
  • Participate in process transfer activities.
Requirements
  • Bachelor's or Master's degree in chemical engineering, biochemical engineering, biochemistry, or a related field.
  • 3-6 years of industry experience in purification process development or a similar role.
  • Proficiency with chromatography instrumentation and control software, especially Äkta systems and UNICORN software.
  • Experience with running characterization and analytical assays.
  • Effective interpersonal communication and presentation skills.
  • Ability to write clear and concise technical documents.
  • Enthusiasm to work with a team to meet shared objectives.
  • Proficiency with Microsoft Office suite, including Excel, PowerPoint, and Word.
Preferred Qualifications
  • Experience with AAV purification and quality parameters.
  • Capability to perform statistical data analysis, including DOE and JMP software.
  • Familiarity with Empower, SoftMax Pro, and other analytical assay software.
What We Offer
  • Competitive salary range: $91,945 - $108,171 (California-based positions) or $77,775 - $91,500 (Process Development Associate II level).
  • Annual bonus and equity under the company's stock plan.
  • Comprehensive benefits package, including competitive employer premium contributions.
  • Meaningful stock option grants.
  • PTO, sick time, and vacation pay.
  • Generous Parental Leave program.
  • Pre-tax medical and dependent care programs.
  • STD, LTD, Life, and AD&D.
  • Professional development opportunities.
  • Team-building events.
  • Fully stocked kitchen.
  • Purple Tie dry cleaning service.
  • Fitness center.

Encoded Therapeutics is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. We are committed to providing a work environment free of discrimination and harassment. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, religion, or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate.



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