Downstream Processing Specialist

4 weeks ago

California, United States Cirsium Biosciences Full time
Job Summary

Cirsium Biosciences is a pioneering biotechnology company dedicated to revolutionizing viral vector production. We are seeking a highly skilled and motivated Downstream Processing Scientist to join our dynamic team.

Key Responsibilities
  • Conduct advanced molecular biology experiments, including vector design, plasmid DNA extraction, PCR, cloning, and sequencing.
  • Extract RNA/DNA/Protein from plants, qPCR, western blotting, enzyme assays, and other functional assays.
  • Operate and maintain fermenters or bioreactors for cultivating microbial and mammalian cells.
  • Culture Agrobacterium and utilize it for efficient plant transformation procedures.
  • Analyze and interpret experimental data, ensuring accuracy and reliability.
  • Collaborate with cross-functional teams to achieve research goals and project timelines.
  • Maintain detailed and organized laboratory records, including experimental protocols, data, and reports.
  • Ensure compliance with all safety and regulatory requirements within the laboratory.
  • Mentor and train junior staff and interns in molecular biology techniques and laboratory protocols.
Requirements
  • Ph.D. or M.S. in Biochemistry, Chemical Engineering, Biotechnology, or a related field, with 2+ years (Ph.D.) or 5+ years (M.S.) of relevant experience in downstream process development in the biopharmaceutical industry.
  • Hands-on experience with downstream processing techniques such as chromatography (affinity, ion exchange, size exclusion), filtration (depth filtration, tangential flow filtration), and UF/DF.
  • Experience with DSP on Plant made pharmaceuticals will be an added plus.
  • Experience with the use of fermenters or bioreactors is a plus.
  • Knowledge of AAV Biology is a plus.
  • Familiarity with process scale-up, technology transfer, and cGMP requirements.
  • Strong problem-solving skills and the ability to troubleshoot complex process issues.
  • Proficiency in data analysis, process optimization, and statistical tools (e.g., Design of Experiments).
  • Knowledge of regulatory guidelines and quality control procedures in a research environment is preferred.
  • Strong analytical and problem-solving skills, with attention to detail.
  • Excellent communication and interpersonal skills.
  • Ability to work independently and as part of a collaborative team.
What We Offer

Cirsium Biosciences offers highly competitive compensation and employee programs, including comprehensive health, dental, and vision plans, generous time off, and equity in our early-stage company. We are dedicated to fostering a workplace that keeps our team inspired and engaged. We offer an inclusive company culture where employees feel respected and valued.

Cirsium Biosciences is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other protected categories.

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