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Senior Pharmacokinetics Scientist

2 months ago

South San Francisco, California, United States Cytokinetics Full time
About the Role

Cytokinetics is a pioneering biopharmaceutical company dedicated to developing innovative treatments for debilitating diseases affecting cardiac muscle performance. As a leader in muscle biology and pharmacokinetics, we're seeking a highly skilled Principal Scientist - DMPK to join our team.

Key Responsibilities
  • Lead and manage in-vivo and in-vitro ADME/PK studies to support drug discovery and early development of small molecules.
  • Collaborate with medicinal chemists to design drug candidates that avoid metabolic liabilities and evaluate them based on potency, ADME profile, and drug-drug interaction liabilities.
  • Mentor and motivate the in-house DMPK team, fostering a collaborative and proactive environment.
  • Provide technical expertise and support in the use of standard PK and PD data analysis software, including Phoenix WinNonlin, NONMEM, and similar tools.
  • Evaluate and interpret in vitro and in vivo DMPK data, working with DMPK colleagues to design studies that address key project issues.
  • Provide scientific expertise on experimental design, data analysis, interpretation, reporting, and leading the PK/PD analysis for the assigned projects.
  • Perform and lead non-compartmental PK modeling.
  • Assist in troubleshooting and routine sample analysis of established bioanalytical methods and develop/optimize method of analysis as needed.
  • Contribute to protocols and reports for IND submissions.
  • Manage and troubleshoot DMPK activities and instrument/assay issues as they arise.
Requirements
  • PhD degree in Pharmacokinetics, Drug Metabolism, or a related life sciences degree with 12+ years of experience in small molecule development; industry experience is highly preferred, but will consider commensurate postdoc experience.
  • Demonstrated experience designing and conducting experiments in support of DMPK lead optimization and candidate selection activities.
  • Hands-on experience designing, analyzing, and interpreting drug metabolism and PK studies.
  • Expertise and experience in the following areas:
    • State-of-the-art bioanalysis by LC/MS/MS and related techniques.
    • Metabolite identification and reactive metabolite chemistry.
    • Hands-on ADME assays like CYP enzymes inhibition, induction, and/or transporters assays.
    • Principals, theories, and approaches to understand pharmacokinetics, drug disposition, and drug interactions.
    • Application of modeling and prediction methods using software packages.
    • Familiarity with a range of laboratory automation instrumentation, including robotic liquid handlers.
About Cytokinetics

Cytokinetics is an Equal Opportunity Employer. Our employees come from diverse backgrounds, and we celebrate those differences. We're passionate about robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do - all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.

Please visit our website at: Cytokinetics.com