Senior Scientist II, Preclinical Bioanalysis

3 days ago

Alameda, California, United States EXELIXIS Full time
Job Summary

Exelixis is seeking a highly skilled Senior Scientist II to join our Preclinical Bioanalysis team within Translational Biology. As a key member of our team, you will provide preclinical bioanalytical support for the advancement of our biologics portfolio. Your expertise in LCMS-based bioanalysis, pharmacokinetics, and pharmacodynamics will be instrumental in driving the success of our oncology programs.

Key Responsibilities
  • Design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices.
  • Perform pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection.
  • Design, implement, and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed.
  • Critically analyze and interpret scientific data from experiments.
  • Collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement.
  • Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.
Requirements
  • Master's degree in analytical chemistry or biology or closely related discipline and a minimum of ten (10) years of related experience; or
  • PhD degree in analytical chemistry or biology or closely related discipline and a minimum of two (2) years of related experience is preferred; or
  • Equivalent combination of education and experience.
  • Hand-on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics is essential.
  • Scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology is important.
What We Offer
  • A competitive salary and benefits package.
  • The opportunity to work with a talented team of scientists and researchers.
  • A dynamic and supportive work environment.
  • The chance to contribute to the development of innovative cancer therapies.

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