Research Associate II, Technical Operations Specialist

2 days ago


Seattle, Washington, United States A-Alpha Bio Full time
About A-Alpha Bio

A-Alpha Bio is a biotechnology company that leverages synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions.

Job Description

We are seeking a highly skilled Research Associate II to support our Technical Operations team's execution of our yeast-based AlphaSeq platform for drug discovery and optimization.

Key Responsibilities
  • Execute DNA library preparation and sequencing workflows for Oxford Nanopore Technologies and Illumina platforms.
  • Perform cell sorting and flow cytometry.
  • Perform yeast transformation and matings.
  • Execute DNA library construction as assigned.
  • Support development and optimization of standard operating procedures for existing and new experimental workflows.
  • Contribute to project teams and execute project-related tasks as needed.
Requirements
  • Bachelor's degree in a relevant field with 2+ years of relevant postbaccalaureate laboratory experience in the biotechnology industry; or an equivalent combination of education and experience.
  • Proficiency in standard molecular biology techniques, including DNA extractions, quantitative PCR, Gibson assembly, and fragment analysis.
  • Experience with multi-parametric flow cytometry.
  • Experience in a high-throughput screening or manufacturing environment.
  • Experience working within a LIMS/ELN.
Preferred Qualifications
  • Operator experience in a regulated environment (e.g., CLIA, cGXP).
  • Hands-on experience with Illumina, ONT, and/or PacBio next-generation sequencing platforms.
  • Experience with cell sorting.
  • Experience using yeast as a model organism.
  • Experience with Benchling.
  • Experience using Lab Automation.
About the Role

This role is not open to remote applicants and would require relocation to Seattle, WA.

We offer competitive compensation, including benefits, flexible time off, and equity in a fast-growing start-up.

Applicants must have legal authorization to work in the United States.

At this time, A-Alpha Bio is unable to offer visa sponsorship in any form.



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