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Medicinal Chemistry Lead
2 months ago
We are seeking a highly skilled Principal Scientist, Medicinal Chemistry to join our team at Flagship Ventures. This is an exciting opportunity to design and execute medicinal chemistry strategies that will support biology validation and drug discovery from hit finding to lead generation, lead optimization, and candidate selection.
Key Responsibilities- Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development
- Define, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization, and candidate selection
- Provide strategic, scientific, and managerial leadership to external CRO med chem teams
- Serve as project and chemistry lead for drug discovery programs
- Collaborate with the IP team to create and execute strategy to establish, protect, and expand intellectual property
- Communicate, collaborate, and coordinate effectively within cross-functional teams
- Effectively present and communicate research findings at internal meetings and external scientific conferences
- Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry
- Experienced in all aspects of medicinal chemistry, including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection
- Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO), and computational chemistry
- Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology
- Experience in managing and building strong relationships with chemistry CROs
- Demonstrated success in leading medicinal chemistry and projects teams to deliver high-quality compounds into development
- Experience in oligonucleotide drug discovery is a plus
- Track record of delivering on project and company goals
- Ability to accommodate rapidly changing priorities and deadlines
- Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting
- Proven track record for striving for a high level of innovation and scientific excellence
