Principal Scientist, Modeling and Simulation

2 weeks ago


Cambridge, Massachusetts, United States Novartis Group Companies Full time
Job Description Summary

Novartis is seeking a highly skilled Translational Modeler to join our PK Sciences Translational Modeling team. As a key member of our team, you will be responsible for developing and executing modeling strategies to accelerate radioligand discovery and development.

Key Responsibilities:
  • Develop and apply innovative QSP and PBPK models to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
  • Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients.
  • Partner with discovery project teams and preclinical safety and pharmacometrics groups to advance the translational science for radiopharmaceuticals.
  • Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
  • Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
Essential Requirements:
  • Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field along with demonstrated expertise in radiobiology/nuclear medicine.
  • Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred.
  • Expert level proficiency in core modeling fundamentals, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
  • Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
  • Fluent in English (oral and written).


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