Principal Scientist, Modeling and Simulation

21 hours ago


Cambridge, Massachusetts, United States Novartis Group Companies Full time
Job Description Summary

Novartis is seeking a highly skilled Translational Modeler to accelerate radioligand discovery and development by facilitating rigorous decision-making with modeling and simulation. This role will be part of a multi-disciplinary environment, with opportunities to engage in cross-functional initiatives.

Key Responsibilities:
  • Develop and execute modeling strategies for radioligand therapy programs, contributing to project team discussions and guiding therapeutic design and dose selection decisions.
  • Build and apply innovative QSP and PBPK models to link RLT pharmacology, tissue biodistribution, mechanism(s) of action, and biological and clinical outcomes.
  • Contribute to an integrated RLT modeling platform that bridges data and knowledge across preclinical species and patients, partnering with discovery project teams and the preclinical safety and pharmacometrics groups.
  • Implement innovative quantitative approaches to advance the translational science for radiopharmaceuticals.
  • Proactively seek opportunities to increase the impact and awareness of translational and clinical modeling through communications with internal and external audiences.
Essential Requirements:
  • Ph.D. in biology, pharmaceutical sciences, bioengineering, biophysics, or a related field, with demonstrated expertise in radiobiology/nuclear medicine.
  • Prior experience in pharmacokinetics and pharmacodynamics (PK/PD), quantitative systems pharmacology (QSP), and/or physiologically based PK (PBPK) modeling is preferred.
  • Expert-level proficiency in core modeling fundamentals, including scripting languages (e.g., MATLAB, R), construction of ordinary differential equation (ODE) models, parameter estimation, and data visualization.
  • Demonstrated ability to communicate modeling results to a multidisciplinary audience to facilitate decision-making.
  • Fluent in English (oral and written).


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