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Senior Scientist/ Principal Investigator
1 month ago
We are seeking an accomplished scientist to join our growing drug discovery team at RPM ReSearch, a leading international organization with a strong presence in the pharmaceutical industry.
The successful candidate will be part of a newly created group at our site, supporting teams at another location. This is an exciting opportunity to contribute to the development of innovative oligonucleotide-based therapeutics and build internal capabilities.
Key Responsibilities- Design and implement novel bioanalytical methods to support research projects related to oligonucleotide-based therapeutics.
- Develop and implement innovative high-resolution mass spectrometry-based metabolite profiling and identification assays.
- Act as an oligonucleotide bioanalytical SME and work cross-functionally to build internal capabilities.
- BS or equivalent degree in Chemistry, Biochemistry, or related field, and greater than 15 years of Analytical and/or Bioanalytical Chemistry laboratory experience, including study management.
- MS in Chemistry, Biochemistry, or related field, and 7 to 10 years of Analytical and/or Bioanalytical Chemistry laboratory experience, including study management.
- Ph.D. in Chemistry, Biochemistry, or related field, and 3 to 5 years of Analytical and/or Bioanalytical Chemistry laboratory experience, including study management.
- 5-10 years of specific experience with oligonucleotides.
- Proven track record of scientific contributions in the development of oligonucleotide analytical and bioanalytical methods.
- Demonstrates inter-disciplinary knowledge of drug discovery, including in vitro/in vivo pharmacology, ADME, PK/PD, translational research, and toxicology.
- Working knowledge and awareness of general laboratory procedures.
- Displays versatility and accuracy performing laboratory operations, some of which may be difficult and/or non-routine.
- Strong and effective manager and mentor of junior scientists.
- Ability to use a computer to compile and maintain databases for records and inventory, utilizing the appropriate software.
- Ability to adhere to all safety regulations and procedures.
- In-depth knowledge and specific understanding of analytical testing needed in drug discovery as it relates to quantitating, characterizing, and further understanding the metabolic fate of ASO and siRNA-based therapeutics and conjugates thereof.
- Support LC-MS instruments operation, daily maintenance, and troubleshooting.
- An attitude for quality, an eye for detail, the ability to follow written instructions, and work with a minimum of supervision.
We offer a comprehensive benefits package, including Medical/Dental/Vision insurance, 401k, bonus potential, and vacation. This is a full-time permanent position.
