Medical Director of Global Neurodegenerative Programs
3 weeks ago
Company Overview
Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins.
The company uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body's own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins.
The company has progressed multiple investigational drugs through clinical development programs, including vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer; ARV-102, targeting LRRK2 for neurodegenerative disorders; and ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma.
In addition, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer.
About Lifelancer
Lifelancer is a talent-hiring platform in Life Sciences, Pharma, and IT. The platform connects talent with opportunities in pharma, biotech, health sciences, healthtech, and IT domains.
Salary & Benefits
We offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families.
Benefits include group medical, vision, and dental coverage, group and supplemental life insurance, and much more.
Job Description
We are seeking an experienced Executive Medical Director with a passion for developing great medicines for neuromuscular and neurodegenerative diseases.
The ideal candidate is a physician with experience of a global drug development program and global filing experience who is enthusiastic about applying their knowledge to improve the lives of patients around the globe.
The individual will be a self-starter with excellent management and leadership capabilities who is seeking to lead and be part of an innovative team that drives the drug development processes from start to finish.
Responsibilities
This role includes but is not limited to:
- Partnering with discovery and biology leadership and providing clinical input and guidance to develop the neuroscience corporate strategy.
- Responsible for trial design of Phase I/II/III research trials targeting neurological diseases.
- Directly supervising and monitoring trial conduct.
- Working closely with all functions of the organization and external partners to manage trial execution and investigators' engagement.
- Collaborating in developing global regulatory plans and playing a key role in regulatory meetings in partnership with regulatory affairs.
- FOLLOWING IMPORTANT DEVELOPMENTS AND RELEVANT TRENDS IN THE SCIENTIFIC LITERATURE AND DEVELOPING/Maintaining CONTACTS WITH EXTERNAL EXPERTS TO SUPPORT UNDERSTANDING OF THE CANDIDATE DRUG EFFECTS AND TO GAIN STRATEGIC INSIGHTS TO THE FURTHER DEVELOPMENT OF STUDY AND OVERALL PROGRAM.
- Developing effective relationships with external providers.
- Providing clinical assessments of potential in-licensing assets, identifying novel therapeutics opportunities as well as critical study design and execution challenges.
- Reviewing written materials and providing editorial comments for clinical study reports and manuscripts.
- Ensuring consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws.
Requirements
A minimum of 5+ years (10+ years strongly preferred) of clinical and managerial experience in drug development, ideally within neurological disease therapeutic areas.
Experience across multiple stages of clinical development, from IND to NDA / BLA.
Global clinical development experience required, and global filing experience strongly preferred.
Technical (Medical and Scientific) experience evaluating targets/agents for in licensing or internal development.
Experience supervising physicians and/or scientific staff in a management or team leader capacity highly desirable.
Excellent interpersonal and public speaking skills are required for this high visibility position.
Demonstrated ability to work in a matrix environment with cross-functional teams.
MUST BE LEGALLY AUTHORIZED TO WORK IN THE US WITHOUT THE NEED FOR EMPLOYER SPONSORSHIP NOW OR AT ANY TIME IN THE FUTURE.
Estimated Salary: $250,000 - $300,000 per year
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