Senior Research Scientist, Preclinical Pharmacology
18 hours ago
PepGen is seeking a highly skilled and innovative Principal Scientist to join our Preclinical Research and Development team in Boston, Massachusetts. As a key member of our team, you will be responsible for leading the development, optimization, and execution of in vitro and in vivo nonclinical pharmacology studies.
Key Responsibilities:
- Establish and validate in vitro and in vivo pharmacology models and assays
- Identify and collaborate with external contract research organizations (CROs) and academic partners for in vitro and in vivo pharmacology studies
- Lead the development and execution of in vitro and in vivo nonclinical pharmacology studies, implementing rigorous data analysis techniques to elucidate pharmacodynamic effects
- Manage nonclinical development studies for PepGen's Enhanced Delivery Oligonucleotide (EDO) programs, supporting pre-candidate and early and late development programs
- Partner with cross-functional teams, including Research Project Team leaders, CMC, Toxicology, Bioanalytical, and Biomarkers functions, to design and interpret nonclinical pharmacology and efficacy studies
- Manage associate scientists and scientific team members, fostering a culture of collaboration, innovation, and scientific excellence
- Maintain clear technical records and prepare summary presentations and reports of ongoing activities for internal and external audiences
Requirements:
- PhD in biomedical science, biochemistry, biology, or related discipline with at least 6+ years of relevant experience in the pharmaceutical industry in preclinical drug discovery and development
- Experience with in vitro and in vivo preclinical disease models and developing medium- to-high-throughput assay formats to support drug development
- Proficient in techniques such as protein and nucleic acid extraction, gene expression analysis, and western blotting
- Experience with managing and/or conducting studies with CROs and demonstrated expertise in skeletal and/or cardiac muscle biology
- Experience working with cell-penetrating peptides, nucleic acids, and/or oligonucleotide conjugates in drug discovery and development is a plus
- Highly motivated scientist with ability to multitask, prioritize work, and thrive in a fast-paced environment
- Proven ability to work independently, think strategically, and be self-motivated, with excellent interpersonal skills and ability to work in a matrix environment
- Excellent communication and presentation skills to efficiently relay information to project teams and senior management
About PepGen
PepGen Inc. is a clinical-stage biotechnology company advancing the next-generation of oligonucleotide therapies to transform the treatment of severe neuromuscular and neurological diseases. Our Enhanced Delivery Oligonucleotide (EDO) platform leverages cell-penetrating peptides to improve the uptake and activity of conjugated oligonucleotide therapeutics. We are generating a pipeline of oligonucleotide therapeutic candidates that target the root cause of serious diseases.
EEO Statement
PepGen is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, age, ancestry, nationality, marital, domestic partnership or civil union status, sex, gender, gender identity or expression, affectional or sexual orientation, disability, veteran or military status, or liability for military status.
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