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Senior Scientist, Systems Biology Expert
2 months ago
Takeda Pharmaceutical is seeking a highly skilled Senior Scientist, Systems Biology to join our team in Cambridge, MA. As a key member of our computational biology group, you will play a critical role in utilizing in silico and systems biology approaches to support Takeda drug discovery and development projects.
Key Responsibilities- Utilize advanced bioinformatics, computational, AI/ML, and graph learning techniques to analyze multi–omic and multi-modal data, and identify novel drug targets, biomarkers, and cellular mechanisms of action across the Gastroenterology and Inflammation portfolio.
- Evaluate the efficacy of potential target candidates through the application of state-of-the-art computational approaches; working closely with experimental, biology, computational genetics, data science, quantitative statistics, engineering, translational medicine, and biomarker teams.
- Report to the Computational Biology Group leader and collaborate with key stakeholders to drive innovative therapies for inflammatory bowel disease, chronic liver disorders, and chronic inflammatory indications in dermatology and rheumatology.
- PhD degree in Systems Biology, Bioinformatics or Computational Biology with 2+ years relevant experience, or MS with 8+ years relevant experience, or BS with 10+ years relevant experience.
- Strong knowledge of molecular biology and genomics.
- Biological knowledge in one or more areas of inflammation and fibrosis (IBD, chronic liver disorders, chronic inflammatory indications in dermatology and rheumatology).
- Demonstrated experience in large scale multi-omics (e.g. bulk or single-cell, spatial sequencing, proteomics, epigenetics, and more), multi-modal data integration, network analysis, and meta-analyses.
- Strong machine learning experience is preferred.
- Statistical analysis experience with working knowledge of regression analysis, multivariate data analysis, and linear/nonlinear mixed effects modeling is preferred.
Takeda offers a competitive salary range of $133,000.00 - $209,000.00, as well as a comprehensive benefits package, including medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits.
Takeda is an equal opportunity employer and welcomes applications from diverse candidates. We are committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
