Senior Scientist, Human Genetics
4 weeks ago
Key Responsibilities:
We are seeking an innovative data scientist with deep knowledge in human genetics and multi-omics to join our team and accelerate drug target discovery.
As a Senior Scientist, Human Genetics, you will lead human genetics projects from ideation to execution, using publicly available and proprietary data, to advance target identification and validation, safety assessment, and patient stratification.
Key responsibilities include:
- Establishing the Human Genetics group strategy
- Closing collaboration with colleagues in various functions across the organization to drive impact and contribute to go-no go decisions across Takeda's drug discovery and development pipeline
- Active contributions to external collaborations to link genetic data to longitudinal phenotypic data from diverse populations
Requirements:
PhD in computational biology, bioinformatics or similar discipline with 6+ years of postdoctoral experience in human genetics research.
Deep experience with GWAS/eQTL/pQTL analyses, fine-mapping and colocalization, Mendelian randomization, WES/WGS sequencing data analyses, and rare variants statistical analyses required.
Track record experience analyzing genetic data linked to longitudinal real-world health data from large biobanks (e.g. UK Biobank, FINNGEN, Genes and Health, All Of Us, Million Veterans Project etc) required
Experience contributing to pre-competitive academic-pharma partnerships preferred.
Strong scientific understanding of molecular biology and genomics, and ability to interpret genetic findings in disease context
Familiarity with pharmaceutical R&D processes and one or more diseases areas of interest of Takeda (neuroscience, gastrointestinal and inflammation) desired
Solid knowledge of Unix, command lines interfaces, and fluency in common scripting and/or programming language (e.g. R, Python, Perl, Java, C/C++)
Solid experience with parallel computing and cloud computing required
This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.
The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
Takeda Pharmaceuticals is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
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