Lead Scientist in Analytical Chemistry

1 week ago


Village of Tarrytown, United States Regeneron Pharmaceuticals, Inc Full time

We are looking for a dedicated Principal Scientist to become a key member of the Analytical Chemistry Group at Regeneron Pharmaceuticals, Inc. This role is centered on the advancement of cutting-edge mass spectrometry technologies to bolster our research and development initiatives. As a Principal Scientist, you will spearhead the analytical development of therapeutic protein candidates throughout the drug development lifecycle, from initial candidate selection to final regulatory submissions.

Key Responsibilities:
  • Oversee the characterization of biotherapeutics, including monoclonal antibodies, bispecifics, and adeno-associated viruses.
  • Responsible for crafting analytical strategies and methodologies to assess quality attributes, conduct risk evaluations, and establish control measures, particularly focusing on post-translational modifications, impurities, and charge variants.
  • Provide analytical expertise and support for formulation development, collaborating with upstream and downstream teams to address real-time challenges in process development.
Qualifications:
  • Strong verbal and written communication skills, along with excellent interpersonal abilities.
  • Experience in preparing regulatory submission documents and a thorough understanding of industry practices related to analytics development.
  • A passion for scientific innovation, coupled with strong leadership capabilities and a collaborative spirit.

This position requires a PhD in chemistry, biochemistry, or a related discipline, with a minimum of 3 years of relevant experience and a record of publications in the field. A solid foundation in liquid chromatography and mass spectrometry, particularly within the biopharmaceutical sector, is advantageous. Expertise in mass spectrometry applications for protein characterization and process development is essential, with a focus on analytical and problem-solving skills, especially with Orbitrap and Triple-quadrupole MS systems. Familiarity with analyzing trace samples, such as single cells, is a plus. Proficiency in LC and MS software, including Xcalibur, MassLynx, MassHunter, and others, is desired. Experience in DIA data analysis is beneficial.

Regeneron is committed to equal opportunity employment, ensuring that all qualified candidates receive consideration without regard to any protected characteristic.

Salary Range (annually): $124,000 - $202,800.00



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