Lead Scientist in Analytical Chemistry

2 weeks ago


Village of Tarrytown, United States Regeneron Pharmaceuticals, Inc Full time

We are looking for a dedicated Principal Scientist to become a vital part of the Analytical Chemistry Group at Regeneron Pharmaceuticals, Inc. This position focuses on pioneering mass spectrometry technologies that bolster our research and development initiatives. In this capacity, you will oversee the analytical progression of therapeutic protein candidates throughout the entire drug development process, from initial candidate selection to final regulatory submissions.

Key Responsibilities:
  • Direct the characterization of biotherapeutics, which includes monoclonal antibodies, bispecifics, adeno-associated viruses, and other related candidates.
  • Take responsibility for formulating analytical strategies and methodologies to identify and assess quality attributes, risk factors, and control measures, including post-translational modifications, impurities related to products and processes, charge variants, and sequence variations.
  • Offer analytical expertise and support for formulation development, collaborating with upstream and downstream teams to address real-time challenges in process development and investigations.
Qualifications:
  • Exceptional verbal and written communication skills, along with strong interpersonal abilities.
  • Proven experience in drafting regulatory submission documents and a solid understanding of industry practices and regulatory guidance in analytics development.
  • A strong passion for science, with demonstrated leadership and a commitment to collaborative contributions.

This position necessitates a PhD in chemistry, biochemistry, or a related discipline, coupled with a minimum of 3 years of relevant experience and a history of publications in the field. A robust background in liquid chromatography and mass spectrometry, particularly in the context of biopharmaceuticals, is advantageous. Expertise in mass spectrometry techniques for protein characterization and process development is essential, along with strong analytical and problem-solving capabilities. Familiarity with software tools related to LC and MS, such as Xcalibur, MassLynx, MassHunter, and others, is preferred. Experience in analyzing trace samples, such as those from single cells, is a beneficial asset.

Regeneron is committed to equal opportunity employment, ensuring that all qualified candidates receive consideration without regard to any protected characteristic as per applicable laws and regulations.

Salary Range (annually): $124,000 - $202,800.00



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