Molecular Biology Associate II

2 weeks ago

Seattle, Washington, United States A-Alpha Bio Full time
Position Overview

A-Alpha Bio is a pioneering drug discovery firm located in Seattle, WA, dedicated to advancing high-impact therapeutics. Our innovative approach combines high-throughput synthetic biology with cutting-edge machine learning to assess protein-protein interactions on a large scale, enabling the discovery of antibodies, molecular glues, and other protein interaction-related therapeutics. We collaborate with top pharmaceutical and biotechnology organizations to enhance drug discovery processes. Additionally, we utilize our laboratory and computational capabilities to develop an internal pipeline of biologics and molecular glues aimed at improving human health.

Note: This position requires relocation to Seattle, WA, and is not available for remote work.

Compensation: Competitive salary range of $73,000 - $87,000 annually.

Employment Status: Exempt

Work Environment: Onsite

Reporting Structure: Reports to the Senior Scientist, Protein Science

Role Responsibilities

As a member of our Protein Science team, you will contribute to enhancing our mammalian protein production capabilities. Your key responsibilities will include:

  • Assisting in the design and assembly of antibody-like molecules for therapeutic evaluation.
  • Employing sterile techniques to perform mammalian cell transfections for expressing designed molecules.
  • Supporting the purification and characterization of proteins developed through your efforts.
Key Duties
  • Execute molecular biology techniques and create protein expression constructs.
  • Manage the upkeep of cell cultures for protein synthesis.
  • Conduct transient transfection experiments utilizing Expi293 or ExpiCHO cell lines.
  • Prepare transfectant supernatants for subsequent protein purification processes.
  • Maintain detailed records of protein expression activities in an electronic lab notebook and update the internal protein database.
  • Engage in educational opportunities related to downstream protein characterization and functional assays.
  • Present experimental findings and results at interdisciplinary team meetings.
  • Perform additional tasks as assigned.
Qualifications & ExperienceRequired
  • Bachelor's degree in a relevant discipline with a minimum of 2 years of applicable experience in an industrial biotechnology setting; or an equivalent combination of education and experience.
  • Expertise in Gibson Assembly and other pertinent molecular biology techniques.
  • Experience in designing and ordering oligonucleotides and gene fragments.
  • Familiarity with construct sequence verification processes.
  • Exposure to practical protein production in a startup environment.
  • Strong communication and organizational abilities.
  • Capability to collaborate effectively within dynamic startup teams.
  • Self-driven, intellectually curious, and enthusiastic about conducting interdisciplinary research in a fast-paced setting.
Preferred
  • Experience with transient protein expression at small to medium scales.
  • Familiarity with ExpiCHO and Expi293 cell culture techniques.
  • Proficiency in biolayer interferometry assays using Octet/Gator systems.
  • Knowledge of protein biophysical characterization methods (HPLC, DSF, Bioanalyzer/SDS-PAGE, ELISA, UV280 NanoDrop, etc.).
  • Experience in antibody formatting and optimizing protein expression.

We provide competitive compensation packages, including benefits, flexible time off, and equity opportunities in a rapidly growing startup. Candidates must possess legal authorization to work in the United States. Currently, A-Alpha Bio is unable to offer visa sponsorship.

About A-Alpha Bio

A-Alpha Bio is at the forefront of biotechnology, utilizing synthetic biology and machine learning to analyze, predict, and engineer protein-protein interactions. Our AlphaSeq platform enables the experimental measurement of millions of protein interaction affinities simultaneously, while our AlphaBind platform leverages this data to train machine learning models for predictive binding based on sequence. Together, these platforms facilitate the discovery and optimization of impactful therapeutics for our pipeline and in collaboration with leading pharmaceutical and biotechnology partners.

Founded in 2018 as a spin-off from the University of Washington's Institute for Protein Design and Center for Synthetic Biology, A-Alpha Bio is committed to fostering a diverse, meritocratic, and supportive team environment. We value a work-life balance and are situated in a region known for its outdoor activities, making it an ideal location for individuals with varied interests and passions.

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