Senior Scientist, Purification Development

7 days ago

Bothell, Washington, United States Immunome Full time
Job Title: Senior / Principal Scientist, PurificationCompany Overview

Immunome is a clinical-stage targeted oncology company dedicated to developing innovative therapies for cancer patients. Our team has a proven track record in designing, developing, and commercializing cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Our pipeline includes a Phase 3 trial for desmoid tumors, as well as INDs expected to be submitted in the first quarter of 2025 for our ROR1 ADC and FAP-targeted radioligand.

Position Overview

The Senior / Principal Scientist in the Purification Team within Antibody Sciences will play a crucial role in advancing our drug development pipeline. You will lead the development of novel therapeutic technologies, including antibodies and conjugated forms with various linkers and payloads. As the leader of the purification development group, you will leverage your expertise to develop robust systems and deliver high-quality materials that support animal studies and drive project progress.

Responsibilities
  • Lead a team in generating original technical ideas and developing strategies.
  • Develop, optimize, and scale-up purification processes for biologic candidates to support early- and late-stage development.
  • Oversee purification strategies for biologic candidates and take full accountability for project deliverables.
  • Operate and possess strong knowledge of TFF systems and AKTA chromatography skid systems, with proficient hands-on experience in clarification equipment.
  • Perform routine downstream purification operations related to AKTA chromatography systems, including system setup, assembly/disassembly, system cleanup, in-process sampling, buffer preparation, and troubleshooting of operational and equipment issues.
Data Analysis and Interpretation
  • Analyze and summarize experimental data from protein quality, quantity, stability, and viscosity assays.
  • Interpret results and communicate their implications for technology development.
  • Familiarity with LIMS (Laboratory Information Management System) for data management.
Project Collaboration
  • Collaborate with colleagues from diverse scientific disciplines, including biology, chemistry, pharmacology, and translational medicine to achieve project goals.
  • Organize data for ease of collaboration with other research teams.
Documentation and Reporting
  • Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
  • Prepare and present research findings to internal teams and contribute to project updates and strategic discussions.
Continuous Learning and Development
  • Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics.
  • Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.
Qualifications
  • Bachelor's, Master's, or PhD in molecular biology, biochemistry, biophysics, or related field.
  • Minimum of 12 years of experience (or 8+ years of experience with a Master's degree, or 5+ with a PhD) in preclinical drug development in the biotechnology or pharmaceutical industry.
  • Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI is required. Large scale is necessary.
Knowledge and Skills
  • Ability to maintain detailed and organized experimental logs.
  • Ability to understand and communicate complex scientific data.
  • Ability to collaborate effectively in a team-oriented environment.
  • Ability to maintain system stability and performance.
  • Experience in protein analytics, such as SDS-PAGE, HPLC-SEC-MALS, DLS, and BLI.
  • A thorough knowledge of protein stability, degradation mechanisms, and excipients is a plus.
  • Deep expertise in ultrafiltration/diafiltration (UF/DF) and tangential flow filtration (TFF) is a strong plus.
  • Experience in CRO management is a plus.
  • A solid track record of peer-reviewed publications and presentations at national-level conferences is a plus.
Equal Employment Opportunity

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Salary Description

$136,000 - $177,000

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