Postdoctoral Research Fellow in Ophthalmology

4 weeks ago


Watertown, Massachusetts, United States Apellis Pharmaceuticals Full time
Job Summary

We are seeking a highly motivated and experienced Postdoctoral Fellow to join our Translational Development group at Apellis Pharmaceuticals. The successful candidate will play a crucial role in advancing our understanding of ocular diseases and developing therapeutic strategies for future clinical practice by targeting the complement cascade.

Key Responsibilities
  • Establish in vivo screening cascades for new ocular therapeutics.
  • Design models of ocular disease, including retinopathies (neovascular, degenerative) and glaucoma.
  • Characterize disease models for changes in relevant biology such as mRNA and protein expression.
  • Contribute to ongoing pharmacokinetic and pharmacodynamic research projects.
  • Gain diverse experience and understanding of pharmaceutical drug development.
Requirements
  • PhD or master's degree with extensive experience in ophthalmology.
  • Experience with vivarium responsibilities including non-clinical ocular imaging, animal handling, intravitreal injection, eye dissection, perfusion.
  • Experience in handling samples from in vivo studies.
  • Basic wet lab skills, including molecular biology and biochemistry techniques such as DNA and RNA extraction, lysate preparation, qPCR, protein quantification, Western blot/WES/JESS, and ELISA.
Preferred Qualifications
  • Experience with in vitro evaluation of various modalities of test article (small molecule, large molecule, oligonucleotide).
  • Experience with novel cell model generation and/or immunoassay development.
What We Offer

Apellis Pharmaceuticals is a global biopharmaceutical company that combines courageous science and compassion to develop life-changing therapies for some of the most challenging diseases patients face. We offer a dynamic and collaborative work environment, opportunities for professional growth and development, and a competitive compensation package.

Equal Employment Opportunity

Apellis is an equal opportunity employer and complies with all applicable federal, state and local fair employment practices laws. We strictly prohibit and do not tolerate discrimination against employees, applicants or any other covered persons because of race, color, religion, creed, national origin or ancestry, ethnicity, sex (including pregnancy), gender (including gender nonconformity and status as a transgender or transsexual individual), age, physical or mental disability, citizenship, past, current or prospective service in the uniformed services, genetic information, marital status, AIDS/HIV status, smoker/nonsmoker, and occupational pneumoconiosis or any other characteristic protected under applicable federal, state or local law.



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