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Senior Scientist in RNA Vaccine Research
2 months ago
Memorial Sloan Kettering Cancer Center (MSK) is on the lookout for a distinguished and driven professional to lead its RNA Therapeutics Laboratory. This role is pivotal in spearheading research and development activities within the newly formed Center for Cancer Vaccines, a cornerstone of MSK's advancements in immuno-oncology.
Key Responsibilities:
- Direct the establishment of a comprehensive mRNA vaccine development pipeline, including optimization of vaccine platforms and ensuring GMP manufacturing for clinical applications.
- Oversee the design and development of RNA vaccines, focusing on enhancements to mRNA templates, structural integrity, stability, and production techniques such as in vitro transcription and lipid nanoparticle encapsulation.
- Manage quality control processes for RNA vaccines, collaborating with research teams to create and refine analytical assays that assess the quality and effectiveness of mRNA products.
- Facilitate the transfer of these assays to the GMP-Therapeutics Core Facility, providing collaborative support for vaccine production.
- Lead and mentor laboratory personnel, fostering a productive and innovative research environment.
- Define the strategic scientific direction of the laboratory, aligning emerging technologies with the needs of MSK's scientific community.
- Oversee operational aspects, including advanced method development and scientific consultations, to maintain a cutting-edge laboratory.
- Manage financial and human resources, including recruitment, training, and professional development of staff.
- Collaborate closely with the MSK GMP-Therapeutics Core Facility to ensure alignment with institutional strategic objectives, reporting to the director of the Cancer Vaccine Center.
- Ph.D. in immunology, cell biology, biochemistry, biophysics, or a related field.
- A minimum of 5 years of experience in either academic or commercial settings.
- Proven expertise in experimental mRNA vaccine biology and the clinical development of GMP-grade mRNA vaccines; experience in assay development is highly desirable.
- Strong background in mRNA customization, synthesis, and purification techniques.
- In-depth knowledge of mRNA-LNP platforms, cGMP processes, and analytical panel development; familiarity with IND applications is a plus.
- Exceptional communication skills, both written and verbal.
- Experience in managing laboratory teams and overseeing daily operations is crucial.
- A seasoned scientist with a keen eye for detail and strong decision-making capabilities.
- A proactive learner and problem-solver, adept at identifying and addressing data anomalies.
- Skilled in multitasking and prioritizing tasks to meet objectives in a dynamic work environment.
- A motivated individual capable of fostering strong relationships within the lab and with external collaborators.
- A mentor with a commitment to the growth and success of team members, providing constructive feedback and performance evaluations.
- An effective communicator, able to tailor messages for diverse audiences, whether in internal meetings or broader institutional presentations.
- A creative strategist, capable of innovative thinking and planning.
- Consistently delivers results, even in challenging situations.
- Schedule: Monday - Friday, standard business hours.
- Reporting Structure: Directly reports to the Director of the Center for Cancer Vaccines.
MSK is committed to fostering diversity and inclusion in all aspects of recruitment and employment. All qualified candidates are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status, or any other factor that cannot lawfully be used as a basis for an employment decision.
