Bone Physiology Research Associate II

1 week ago


Boston, Massachusetts, United States Mass General Brigham Full time

Position Overview: The selected candidate will contribute to our research endeavors focused on bone physiology, specifically examining the dynamics of bone resorption and formation through the study of osteoclasts and osteoblasts. Utilizing animal models, our investigations encompass advanced imaging techniques, histological assessments, and molecular biology methodologies.

Key Responsibilities:

  • Manage breeding colonies of various mouse strains, including setting up breeding environments, preparing genotyping materials, conducting PCR, and interpreting genotypic results while maintaining meticulous records.
  • Design and implement research experiments, analyze outcomes, and troubleshoot necessary techniques with guidance from supervisors. Responsibilities may include isolating bones for histological or micro-computed tomographic evaluations, generating and annotating images, and performing data analysis using software such as Graph Pad Prism.
  • Conduct ELISA assays on mouse serum and cell culture supernatants, isolate primary cells for short-term culture, and assess cellular functions through various in vitro assays.
  • Maintain laboratory operations, including preparing media, ensuring the cell culture area is well-maintained, and creating various stock solutions.
  • Execute additional duties as assigned by supervisors.

Qualifications:

  • A Bachelor’s degree in a biological or physical science is essential; prior laboratory experience beyond coursework is advantageous.

Required Skills and Competencies:

The ideal candidate will possess a comprehensive understanding of scientific principles, biological structures, and laboratory techniques, typically gained through a degree in biological sciences. Candidates with backgrounds in chemistry or engineering are also encouraged to apply. Familiarity with basic laboratory instruments and procedures is expected, along with a high level of computer proficiency.

Essential attributes include self-motivation, sound judgment, and the ability to identify and resolve potential issues. Strong organizational, communication, and time management skills are critical for success in this role. Previous experience in a research laboratory (3-6 months) or relevant coursework is preferred.

Work Environment:

This position will primarily be conducted in a laboratory setting, with approximately 70% of the time spent at the bench and 30% in an office environment.



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