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Research Scientist in Cellular Therapeutics
2 months ago
Position: Scientist, Discovery Research
Department: Research and Development
Company: Capstan Therapeutics, Inc.
Capstan Therapeutics, Inc. is a cutting-edge biotechnology firm focused on pioneering in vivo cell reprogramming technologies. Our proprietary platform utilizes targeted lipid nanoparticles (tLNPs) that integrate lipid nanoparticles with recombinant protein binders, such as monoclonal antibodies. These tLNPs are engineered to deliver therapeutic payloads, including mRNA and gene editing tools, aimed at reprogramming specific cell types within living organisms. This innovative technology holds the promise of developing transformative therapies applicable to a wide array of diseases, including autoimmune conditions, cancer, fibrosis, and genetic blood disorders.
Position Summary
We are seeking a driven Scientist in Protein Engineering to enhance CAR T design and optimization, working collaboratively with both internal teams and external partners. The primary focus of this role will be to refine novel mRNA-based CAR T constructs for in vivo applications across various therapeutic areas.
Key Responsibilities:
- Lead the discovery of product candidates by devising and implementing detailed research strategies.
- Engage in all facets of antibody discovery and receptor engineering, including library design, screening, and binder identification to achieve program objectives.
- Develop CARs, multi-format antibody constructs, and other protein-based entities for both cell-based and recombinant expression.
- Formulate molecular biology strategies for cloning relevant constructs and constructing libraries.
- Create plasmids and lentivirus vectors.
- Employ advanced techniques such as electroporation, viral delivery, and nanoparticle transfections to modify mammalian cells.
- Utilize flow cytometry and cell-based functional assays to thoroughly characterize mammalian cells.
- Perform meticulous mammalian cell culture procedures adhering to aseptic techniques.
- Ensure compliance with stringent laboratory standards, including detailed documentation in an online laboratory notebook, instrument validation, and personal safety protocols.
- Build collaborative relationships within a cross-functional team environment, acting as a key contributor to project teams focused on developing, refining, and standardizing cell-based assays across multiple initiatives.
- Effectively organize and communicate data through written and verbal channels, actively participating in project team discussions.
Qualifications:
- Ph.D. in a relevant scientific discipline (preferably Protein Engineering, Immunology, Cell Biology, or related fields) with a minimum of 2 years of industry experience or equivalent.
- Expertise in structure-based engineering of CARs, antibodies, and/or other proteins.
- Proficient in molecular biology techniques, including Gibson, Golden Gate, and library construction methodologies.
- Strong background in mammalian display and NGS methodologies for antibody discovery and CAR-T engineering is highly desirable.
- Prior experience in the development of antibody therapeutics, particularly bispecific or ADC, is advantageous.
- Demonstrated success in producing lentivirus/retrovirus and engineering primary T cells for CAR or TCR production.
- Familiarity with non-viral gene transfer techniques for mammalian cell engineering is a plus.
- Experience in designing and executing assays to assess T cell functionality, including evaluations of cytotoxicity, activation, proliferation, and cytokine production.
- Knowledge of plate-based assay development and proficiency in automated liquid handling systems is beneficial.
- Familiarity with scientific data analysis software such as GraphPad Prism, FlowJo, or CellEngine, and experience analyzing large datasets using R, Python, or other computational tools is advantageous.
- Proven ability to conceive and execute research projects independently while contributing to team efforts.
- Strong organizational and time-management skills, with the ability to manage multiple projects effectively and maintain thorough documentation practices.
- Excellent communication and interpersonal skills, with a strong team-oriented mindset.
- Capacity to be adaptable, responsive, and highly organized with meticulous attention to detail.
- Strong analytical and problem-solving capabilities.
- Able to thrive in a fast-paced, dynamic work environment.
Compensation and Benefits:
- Competitive salary range of $105,000 - $140,000/year, commensurate with experience.
- Performance-based bonuses.
- Employee Stock Option Program.
- 401(k) plan with employer matching contributions.
- Comprehensive medical, dental, and vision coverage.
- Short- and long-term disability insurance.
- Flexible Spending Account (FSA) options.
- Paid Time Off (PTO) and company-paid holidays.
- Employee Assistance Program.
- Access to fully stocked kitchens on-site.
Capstan Therapeutics is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We do not discriminate based on race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status.
