Senior Research Associate

2 weeks ago

CA United States Scribe Therapeutics Full time
Job Title: Senior Research Associate - Discovery Biology

Scribe Therapeutics is a molecular engineering company focused on creating innovative in vivo therapies that address the root cause of diseases. Our team is dedicated to developing custom engineered enzymes and delivery modalities as part of our proprietary CRISPR by Design platform for CRISPR-based genetic medicine.

We are seeking a highly motivated and experienced Senior Research Associate to join our discovery team in advancing our ongoing efforts to engineer highly active and specific CRISPR enzymes. The ideal candidate will have a strong background in molecular biology and in vitro models, with a passion for characterizing CRISPR systems that advance our therapeutic programs.

Key Responsibilities:

  • Design, build, and screen therapeutic constructs with the discovery team.
  • Develop and execute in vitro molecular and cell-based assays, analyze and present results.
  • Conduct in vitro characterization (phenotypic, genomic, functional) of genome-edited cells.
  • Communicate research plans and results to team members verbally and in writing.
  • Collaborate effectively with members within a fully integrated team to facilitate project execution within established timelines.

Requirements:

  • Bachelor's and/or Master's Degree in Biology, Bioengineering, Physiology, Genetics, or related discipline.
  • At least 3 years of experience (with a Master's) or at least 5 years working in an academic or industry lab, with a proven track record of expertise in cellular and molecular biology.
  • Extensive experience with molecular biology techniques, including protein (Western, ELISA, IF), DNA, and RNA-based assays (qPCR, ddPCR).
  • Familiarity with principles of transcriptional gene regulation and associated molecular and -omics approaches (e.g. RNA-seq, BS-seq, ChIP-seq).
  • Familiarity with assay development and qualification principles.

Preferred Skills and Background:

  • Experience culturing primary cells and in vitro models of liver diseases and metabolism.
  • Experience with CRISPR-Cas gene editing systems and delivery technology.

What We Offer:

We provide a competitive salary, comprehensive medical and other benefits, and a dynamic work environment that fosters innovation and collaboration. If you are passionate about engineering the future of therapeutics, we encourage you to apply.

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