Senior Scientist, Biology

2 weeks ago

Reston, Virginia, United States Firefly Bio Full time

About Firefly Bio:

Firefly Bio specializes in the development of innovative drug conjugates, combining the strengths of Antibody Conjugates (ADCs) with selective protein degraders. Our mission is to unlock the full potential of bioconjugates and develop medicines with long-lasting benefits for patients. We are establishing a team of experts to build state-of-the-art platform capabilities for the invention and development of novel drug conjugates. Our company culture is built on the values of Focus, Integrity, Respect, and Energy. We are seeking passionate individuals committed to making an impact on the future of medicine.

Position Summary:

The Senior Scientist in Biology will lead the development and execution of in vitro studies to evaluate novel drug conjugates for applications in oncology and other areas of unmet medical need. The position is lab-facing and on-site. Title and compensation package will be based on experience and relevant skills.

Key Responsibilities:

  • Drive and execute on the development and optimizations of in vitro biochemical and cellular assays to evaluate novel payloads, antibodies, and drug conjugates on cell culture and ex vivo samples.
  • Oversee and contribute to the design and execution of in vitro studies for target validation.
  • Establish robust in-house capabilities to perform in vitro experiments with high throughput.
  • Contribute to the understanding of program biology and participate in new target recommendations.
  • Collaborate cross-functionally with protein sciences and chemistry teams.
  • Oversee cell line procurement, evaluation of optimal culture conditions, expansion, storage, and cell line inventory.
  • Participate in biology and project teams with clear communication and presentations.

Requirements and Experience:

  • Ph.D. with a degree in cancer, cell, or molecular biology or a closely related field with > 6 years of experience or equivalent.
  • Strong hands-on experience in designing and executing in vitro experiments to validate targets and treatment ideas using ADCs, mAbs, degraders, or small molecules.
  • Expertise in target validation and cell signaling work is preferred.
  • Experience with flow cytometry, cell culture, cell viability assays, Western blot analysis, cell-based fluorescence and chemiluminescence assays, and cell line engineering.
  • Proven capabilities in maintenance of cell line health and longevity.
  • Experience with handling animal and human tissues.
  • Highly organized, diligent, and quality-focused with good computer and documentation skills.
  • Creativity and problem-solving skills paired with the ability to excel in a highly collaborative environment.
  • Excellent oral and written communication and interpersonal skills.

Additional Skills:

  • Good utility of bioinformatic tools for target validation.
  • Experience in IHC and/or proteomics.

Benefits:

Every team member is essential in shaping Firefly Bio's culture and science and for our success. We offer competitive compensation packages, including stock options, and the opportunity to be part of groundbreaking research. Firefly Bio is an equal opportunity employer and will consider all applicants for employment. Firefly Bio does not discriminate based on race, sex, color, religion, age, national origin, marital status, disability, veteran status, genetic information, sexual orientation, gender identity, or any other reason prohibited by law in provision of employment opportunities and benefits.

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