Senior Scientist
17 hours ago
We are seeking an experienced Senior Scientist to join our team at SystImmune Inc., a dynamic clinical-stage bio-pharmaceutical company. As a key member of our research team, you will be responsible for designing and executing display-based campaigns to develop breakthrough-therapeutic multi-specific antibodies and ADCs.
Key Responsibilities- Design and execute protein engineering campaigns to optimize binder and effector molecules, including affinity modulation, stability optimization, and development of novel properties.
- Develop and implement efficient methods for executing engineering campaigns, including library generation and sample preparation, NGS sequencing, and flow cytometry-based lead selection.
- Construct immune-based repertoires from immunized animal sources for use in discovery and protein engineering campaigns.
- Analyze large datasets to inform iterative protein design and optimize lead molecules.
- Stay up-to-date on advancements in instrumentation, software, and methodologies used in display-based protein engineering.
- Conduct biophysical characterization using Octet BLI, Prometheus Panta, and other techniques.
- Troubleshoot technical issues and implement solutions to optimize lead molecules and ensure data quality and integrity.
- PhD in bioengineering, biochemistry, structural biology, molecular biology, cell biology, or a related field.
- 3+ years of industrial drug development experience, preferably in display-based protein engineering.
- Experience with display technologies, including yeast and phage, to discover and engineer novel binders and lead molecules.
- Proficiency in library design and generation, display-based selection, protein engineering, and assay development.
- Excellent problem-solving skills and ability to troubleshoot technical issues.
- Strong communication and interpersonal skills, with the ability to collaborate effectively within multidisciplinary teams.
This role will work in a cell culture laboratory alongside other scientists and in a standard business office with desktop business equipment and a moderate noise level.
Physical DemandsThis role requires regular sitting for long periods and the ability to operate standard laboratory and business equipment.
BenefitsSystImmune offers a comprehensive benefits package, including 100% paid employee premiums for medical/dental/vision, STD, LTD, a 401(k) plan with a 50% company match, 15 PTO days per year, sick leave, and 11 paid holidays.
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