Scientist, Preformulation Specialist

3 weeks ago


Cambridge, Massachusetts, United States The Steely Group Full time
Job Title: Scientist, Preformulation

We are seeking an exceptional candidate to contribute to preformulation research in a small, fast-paced, and highly collaborative team within The Steely Group.

Job Summary:

The ideal candidate will have a strong foundation in analytical techniques such as UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments. Experience in preformulation development and physicochemical characterization is highly desired, but not required.

Responsibilities:
  • Prepare buffers and common lab solutions
  • Execution of analytical experiments with XRPD, DSC, TGA, DVS, SEM, optical microscopy, and UPLC/HPLC (Empower)
  • Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations to enable non-GLP and GLP pre-clinical studies
  • Perform drug substance and formulation stability studies to ensure optimal formulation design
  • Coordinate vehicle/formulation preparations for in vivo studies
  • Execute dissolution studies (Distek and Pion µDISS) to support formulation development and FIH development
  • Maintain an accurate, timely, and compliant laboratory notebook
Requirements / Qualifications:
  • B.S. degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering, or material sciences
  • 2+ years' experience working in pharmaceutical sciences (preformulation, analytical, or formulation development)
  • Experience in the Discovery and Development interface [desirable not required]
  • Experience working with common excipients and volumetric glassware
  • Proficiency with UPLC/HPLC and Empower Software
  • Some knowledge of and interest in learning more about small molecule and pre-clinical formulation development
  • Ability to effectively prioritize and manage multiple tasks and compounds
  • Self-motivated and willing to "learn on the job" and ask for assistance when needed
  • At home in a results-driven, highly accountable environment where you can make a clear impact
  • A team player, who listens effectively and invites responses and discussion
  • A collaborator who communicates in an open, clear, complete, timely, and consistent manner


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