Preformulation Research Scientist

4 weeks ago


Cambridge, Massachusetts, United States The Steely Group Full time
Preformulation Research Scientist

We are seeking a highly skilled Preformulation Research Scientist to join our team at The Steely Group. As a key member of our Formulations Sciences group, you will contribute to the execution of laboratory activities related to the transition of novel small molecule compounds from Discovery into Development.

Key Responsibilities:

  • Prepare buffers and common lab solutions
  • Execution of analytical experiments with XRPD, DSC, TGA, DVS, SEM, optical microscopy, and UPLC/HPLC (Empower)
  • Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations to enable non-GLP and GLP pre-clinical studies
  • Perform drug substance and formulation stability studies to ensure optimal formulation design
  • Coordinate vehicle/formulation preparations for in vivo studies
  • Execute dissolution studies (Distek and Pion μDISS) to support formulation development and FIH development
  • Maintain an accurate, timely, and compliant laboratory notebook

Requirements:

  • B.S. degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering, or material sciences
  • 2+ years' experience working in pharmaceutical sciences (preformulation, analytical, or formulation development)
  • Experience in the Discovery and Development interface [desirable not required]
  • Experience working with common excipients and volumetric glassware
  • Proficiency with UPLC/HPLC and Empower Software
  • Some knowledge of and interest in learning more about small molecule and pre-clinical formulation development
  • Ability to effectively prioritize and manage multiple tasks and compounds
  • Self-motivated and willing to 'learn on the job' and ask for assistance when needed
  • At home in a results-driven, highly accountable environment where you can make a clear impact
  • A team player, who listens effectively and invites responses and discussion
  • A collaborator who communicates in an open, clear, complete, timely, and consistent manner


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