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Senior Research Scientist, In Vivo Pharmacology

2 months ago

South San Francisco, California, United States Merck Sharp & Dohme Full time
Job Title: Principal Scientist, In Vivo Pharmacology

At Merck Sharp & Dohme, we are committed to advancing human health through innovative research and development. Our Research Laboratories in South San Francisco is seeking a Principal Scientist of In Vivo Pharmacology with expertise in cardiovascular and metabolic diseases to lead our Quantitative Biosciences department.

Key Responsibilities:
  • Develop and support in vivo pharmacology strategies for obesity, immuno-metabolic, and cardiovascular diseases.
  • Lead translational model development and implementation to support target engagement, pharmacodynamics, or efficacy studies.
  • Serve as a core member in matrixed project teams and governance committees to drive in vivo pharmacology strategy and provide scientific/technical leadership.
  • Ensure high-quality data generation, analysis, and reporting to project teams, governance committees, and regulatory agencies.
  • Lead and develop a group of PhD and non-PhD researchers, drive scientific innovation, and champion new enabling technologies.
  • Monitor emerging biology, biomarker, and basic & clinical research in cardiometabolic disorders to influence portfolio development strategy.
Qualifications:
  • Ph.D. in biology, pharmacology, metabolism, immunology or related discipline and relevant industry experience.
  • A minimum of 10 years of drug discovery experience in obesity, dysmetabolism, diabetes, and cardiovascular complications.
  • Strong understanding of cardiometabolic disease pathogenesis and experience in developing relevant in vivo models.
  • Experience leading discovery teams, overseeing in vivo strategy, setting project priorities, and managing resources.